Fig. 6

Intestinal microbiota contributes to decreased colitis in RhoB-deficient mice. A Schematic image illustrating FMT experimental design. B Disease activity index of the indicated mice and treatments. C Measurement and quantification of colon lengths in the indicated mice and treatments. D Histopathological changes and quantitation of histology score in colon of the indicated mice and treatments. n = 10 from 2 independent experiments (B–D). E–I Mice were cohoused for 4 weeks and then treated with 1.5% DSS (n = 8 from 2 independent experiments). E Disease activity index of WT and RhoB^+/− mice. F Disease activity index of WT and RhoB^−/− mice. G Measurement and quantification of colon lengths in WT and RhoB^+/− mice. H Measurement and quantification of colon lengths in WT and RhoB^−/− mice. I Histopathological changes and quantitation of histology score in colon of WT, RhoB^+/−, and RhoB^+/− mice. Scale bar: 50 μm. Data are the mean ± SD. Two-way ANOVA (B, E, and F), unpaired Student’s t test (G–I), or one-way ANOVA (C, D). NS, not significant. *p < 0.05, ****p < 0.0001