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Fig. 7 | Microbiome

Fig. 7

From: Metagenomics-resolved genomics provides novel insights into chitin turnover, metabolic specialization, and niche partitioning in the octocoral microbiome

Fig. 7

Secondary metabolite coding potential in each MAG obtained from microbial metagenomes of healthy and necrotic octocoral samples and seawater. a Distribution of secondary metabolite biosynthesis gene clusters (SM-BGCs) across the 66 MAGs of this study. Symbols above bars indicate the origin of each MAG (same as in Fig. 3). SM-BGC counts per compound class were obtained using antiSMASH v.5.0 with default detection strictness (and all extra features on). PKS, polyketide synthase; hglEKS, heterocyst glycolipid synthase-like PKS; NRPS, nonribosomal peptide synthetase cluster; TfuA related, TfuA-related ribosomal peptides. b Percentage of SM-BGCs, identified on the 66 MAGs, with a hit to SM-BGCs of known compounds present in the MIBiG database. Only 14 of the 163 SM-BGCs obtained in this study shared 60% or more similarity to SM-BGCs of known compounds, highlighting the high degree of novelty encoded in these MAGs. c Predicted compounds among the SM-BGCs identified in the MAGs. d Chemical structures of isocalide A and bicornutin A1, encoded in the octocoral-derived MAGs of JAAAOG01 EV04H_Bin1 (Ca. Inquilinaceae, Alphaproteobacteria) and DT-91 LS06H_Bin2 (Pseudomonadales, Gammaproteobacteria). Structures were drawn with ChemDraw v. 12.0.2

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Microbiome

ISSN: 2049-2618

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