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Fig. 1 | Microbiome

Fig. 1

From: Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate

Fig. 1

Gut microbiota and dietary regimen regulate intestinal and circulating succinate levels. Succinate levels in the cecum (a), colon (b), and serum (c) of conventional C57BL/6 (CVN) and germ-free (GF) mice (n = 16–19: males = 9–10; females = 7–9). Circulating succinate determination after intra-colon administration of 500 mg/kg of disodium succinate (or saline as vehicle) in C57BL/6 wild-type mice fed with chow diet (CD) (n = 4) (d). Succinate levels in the cecum (e), feces (f), and serum (g) of C57BL/6 mice fed high-fat diet (HFD) or CD (n = 10). Data are expressed as mean + s.e.m (a–d,f) or % over control (e). *p < 0.05; **p < 0.01; ***p < 0.001 (unpaired t-test and two-way ANOVA)

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Microbiome

ISSN: 2049-2618

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