Fig. 3

Gut microbiome taxa and metabolite levels differed significantly between CDI recurrent and non-recurrent participants. A Univariate analyses of 16S rRNA gene amplicon sequencing data found 51 out of 237 amplicon sequencing variants (ASVs) (post-filtering to remove rare or low-variance taxa), were significantly differentially abundant between recurrers versus non-recurrers. B Univariate analyses of LC/MS untargeted metabolomics found 22 out of 1387 metabolites (post-filtering to remove rare or low-variance metabolites), were significantly differentially abundant between recurrers versus non-recurrers. Metabolite levels shown are log-transformed and standardized. R = recurrers, NR = non-recurrers. Arrows denote the direction of the statistically significant effect. Participants (columns) were ordered in the figure via hierarchical clustering