Fig. 7
From: Gut microbiome mediates the protective effects of exercise after myocardial infarction
3-HPA and 4-HBA mediate cardiac protection through activating NRF2. A, B 3-HPA (100 μM, 24 h) reduced the percentage of TUNEL staining positive cardiomyocytes (n = 6:6:6:6), Bax/Bcl2, cleaved Caspase3/Caspase3, NRF2 (n = 3:3:3:3) in NRCMs under oxygen glucose deprivation/reperfusion (OGD/R). C, D 4-HBA (100 μM, 24 h) decreased the percentage of TUNEL staining positive cardiomyocytes (n = 6:6:6:6), Bax/Bcl2, cleaved Caspase3/Caspase3, NRF2 (n = 3:3:3:3) in NRCMs under OGD/R. E, F Inhibition of NRF2 increased the percentage of TUNEL staining positive cardiomyocytes decreased by 3-HPA and 4-HBA in NRCMs under OGD/R (n = 6:6:6:6). Scale bar: 100 μm. Data were represented as mean ± SD. Significant differences were assessed by two-way ANOVA followed by Bonferroni's multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001 versus respective control