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Table 3 OTUs significantly associated with bacterial vaginosis (BV) at FDR level of 0.05. TF, TreeFDR; SO, Single-OTU test implemented by POST with c = 0; DE, DESeq2; AB, ANCOM-BC; LD, LinDA; WR-P, Wilcoxon rank-sum test using proportional data; WR-R, Wilcoxon rank-sum test using the CLR transformed data

From: Phylogeny-guided microbiome OTU-specific association test (POST)

OTU FDR-adjusted p-value Detected method Genus/species Direction**
  POST TF SO DE AB LD WR-P* WR-R*    
OTU3 0.039 0.089 0.045 0.002 0.006 0.041 0.178 0.025 POST/SO/DE/AB/LD/WR-R Lactobacillus crispatus -
OTU90 0.039 0.245 0.953 0.950 0.983 0.961 0.375 0.989 POST Lactobacillus sp. +
OTU7 0.039 0.653 0.881 0.147 0.766 0.729 0.760 0.932 POST Lactobacillus jensenii -
OTU82 0.039 0.517 0.985 0.970 0.963 0.976 0.258 0.989 POST Lactobacillus gasseri -
OTU66 0.039 0.544 0.701 0.027 0.379 0.615 0.378 0.932 POST/DE Lactobacillus sp. -
OTU2 0.039 0.180 0.917 0.876 0.766 0.923 0.235 0.989 POST Lactobacillus iners +
OTU58 0.039 0.839 0.917 0.876 0.871 0.923 0.791 0.989 POST Lactobacillus sp. +
OTU112 0.411 0.046 0.701 0.422 0.379 0.678 0.040 0.932 TF/WR-P Peptoniphilus sp. +
OTU85 0.470 0.046 0.906 0.372 0.766 0.870 0.097 0.989 TF Gemella sp. +
OTU11 0.918 0.286 0.943 0.000 0.869 0.923 0.220 0.989 DE Prevotella sp. +
OTU12 0.391 0.089 0.701 0.013 0.338 0.615 0.040 0.942 DE/WR-P Prevotella sp. +
OTU16 0.680 0.155 0.881 0.001 0.766 0.918 0.097 0.989 DE Prevotella timonensis +
OTU91 0.680 0.092 0.881 0.505 0.766 0.852 0.040 0.989 WR-P Prevotella sp. +
  1. *WR-P and WR-R did not adjust for race
  2. **+ (and −) indicates that the OTU is positively (and negatively) associated with BV risk from a logistic regression