Fig. 6.

Analyses of T2D dataset. A The number of clusters with different completeness levels were shown at two contamination levels. All programs were run with their default parameters. DASTool was run with two combinations: (1) DASTool_MM for MetaDecoder and MetaBAT2; (2) DASTool_CM for CONCOCT and MetaBAT2. MetaDecoder with minimum sequence length setting to 1 Kb (MetaDecoder1000) was also added for benchmarking. B Differential abundance of genus Holdemanella in T2D (n = 53), IGT (n = 49), and NGT (control, n = 43) samples. Relative abundance was estimated using CheckM and its profile function. Significance was determined using Wilcoxon rank-sum test