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Fig. 1 | Microbiome

Fig. 1

From: Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers

Fig. 1

Metabolomic data profiles and pathway enrichment analysis. A Principal component analysis (PCA) for CRC, CRA and NC groups. B Partial least squares-discriminant analysis (PLS-DA) for CRC, CRA and NC groups. C Z-score heatmap of 17 significantly altered metabolites between CRC and NC. D Z-score heatmap of 36 significantly altered metabolites between CRC and CRA. Significantly altered metabolites were determined using VIP score from pairwise PLD-DA analysis and Wilcoxon rank-sum test, with VIP > 1 and p < 0.05 as the cut-off for significance. CRC; colorectal cancer, CRA; colorectal adenoma, NC; normal control. E Metabolomic pathway enrichment analysis using the 17 significantly altered metabolites between CRC and NC. F Metabolomic pathway enrichment analysis using the 36 significantly altered metabolites between CRC and CRA. CRC; colorectal cancer, CRA; colorectal adenoma, NC; normal control

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Microbiome

ISSN: 2049-2618

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