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Table 1 CBT-related changes in resting-state functional connectivity in responders and non-responders

From: Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement

 

Analysis Unit

 

t statistic

df

p value

q value

Cohen’s d

Interpretation

Responders to CBT

      

 Right anterior transverse temporal gyrus (Heschl’s Gyrus)—right anterior insula (anterior segment of the circular sulcus of the insula)

−4.07

117

.0001

.014

−0.75

Decrease after CBT

 Left anterior insula (inferior segment of the circular sulcus of the insula)—right planum temporale

−4.00

117

.0001

.018

−0.74

Decrease after CBT

 Left anterior insula (left anterior segment of the circular sulcus of the insula)—right aMCC

−3.80

117

.0002

.038

−0.70

Decrease after CBT

 Right amygdala—right lateral aspect of the superior temporal gyrus

−3.79

117

.0002

.040

−0.70

Decrease after CBT

 Right anterior insula (anterior segment of the circular sulcus of the insula)—right planum polare of the superior temporal gyrus

−3.59

117

.0005

.040

−0.66

Decrease after CBT

 Brainstem—right planum temporale

−3.44

117

.0008

.044

−0.64

Decrease after CBT

 Brainstem—right anterior transverse temporal gyrus (Heschl’s Gyrus)

−3.40

117

.0009

.044

−0.63

Decrease after CBT

 Brainstem—left lateral aspect of the temporal gyrus

−3.36

117

.001

.044

−0.62

Decrease after CBT

 Right anterior insula (anterior segment of the circular sulcus of the insula)—left anterior transverse temporal gyrus (Heschl’s gyrus)

−3.42

117

.0009

.048

−0.63

Decrease after CBT

Non-responders to CBT

 

 Right dPCC—right vPCC

−3.74

117

.0003

.047

−0.69

Decrease after CBT

 Right inferior occipital gyrus and sulcus—right middle frontal gyrus

−3.74

117

.0003

.047

−0.69

Decrease after CBT

  1. Abbreviations: df degrees of freedom, CBT cognitive behavioral therapy, aMCC anterior mid-cingulate cortex, dPCC dorsal posterior cingulate cortex, vPCC ventral posterior cingulate cortex