Fig. 6
From: Prevotella copri increases fat accumulation in pigs fed with formula diets
Confirmation of the causal role of P. copri in host fat accumulation. Live P. copri was administrated by oral gavage to germ-free mice three times per week at a dose of 100-μl bacterial suspension (1 × 107 CFUs/μl). a qPCR confirmed the successful colonization of P. copri in germ-free mice. The Y-axis indicates the RQ values reflecting the relative abundance of P. copri in gavaged mice. b Comparison of body fat percentage (%) and epididymal fat percentage (%) among P. copri-gavaged mice (n = 7), P. copri-gavaged mice fed a high-fat diet (n =7), and control mice (n =7). Compared with control mice, P. copri colonization significantly increased host fat accumulation in both normal-chow mice and high-fat-feeding mice. c Comparison of serum concentrations of LPS endotoxin and LBP among experimental mouse groups. d Comparison of serum concentrations of FABP2, zonulin, and DAO among experimental mouse groups. e Comparison of serum concentrations of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, and IFN-γ) among experimental mouse groups. f Comparison of the KEGG pathways enriched by differential serum metabolites among experimental mouse groups. The red circles represent experimental mouse groups, and the sizes of red circles indicate the enrichment by differential metabolites. g Metabolites that differed in normalized abundance among experimental mouse groups. *P < 0.05, **P < 0.01, ***P < 0.005, all P values were adjusted for the multiple tests