Fig. 1

Between-class analysis of phylogenetic and functional profiles in health and disease. Nonmetric multidimensional scaling (NMDS) and receiver operating characteristic (ROC) curves shown. The first three dimensions of species-level (a) and gene-level (b) Bray-Curtis distances are shown (p-value < 0.001 for a and b). Each purple circle represents one of 59 subjects with periodontitis and each yellow circle represents one of 25 periodontally healthy individuals. The ability of disease-specific and health-specific indicators to predict each state is shown in c (phylogenetic metrics) and d (functional metrics)