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Fig. 5 | Microbiome

Fig. 5

From: A semi-tryptic peptide centric metaproteomic mining approach and its potential utility in capturing signatures of gut microbial proteolysis

Fig. 5

Signatures of altered microbial proteolysis at different levels in the fecal metaproteome of IBD. Normalized relative abundance of semi-tryptic peptides (NRASP) reveals altered microbial proteolysis at different taxonomic levels (a) as well as in different biological processes (b) and enzyme sub-classes (c). d Hierarchical clustering analysis of altered amino acid frequencies around the cleavage sites of microbial proteins in IBD. Partial least squares discriminant analysis (PLS-DA, e) of amino acid frequencies around the cleavage sites. Dunn-Bonferroni post hoc analysis following Kruskal-Wallis test was employed to detect significant difference among three groups (CD, Ctrl, and UC). *P < 0.05 versus Ctrl; **P < 0.01 versus Ctrl; ***P < 0.001 versus Ctrl; #P < 0.05 (CD versus UC); ##P < 0.01 (CD versus UC); ###P < 0.001 (CD versus UC)

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Microbiome

ISSN: 2049-2618

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