Fig. 2
From: Modulating gut microbiota in a mouse model of Graves’ orbitopathy and its impact on induced disease
Effect of treatments, immunizations and time on the GO model gut microbiota. a Differences between immunizations at each timepoint and per treatment. PERMANOVA with 999 permutations, ***P = 0.008 and **P = 0.016 (n mice/treatment/immunization at baseline: control TSHR = 10, βgal = 6; hFMT-TSHR = 9, βgal = 6; Lab4 TSHR = 9, βgal = 5; vancomycin TSHR = 12, βgal = 8) (n mice/treatment/immunization at mid-timepoint: control TSHR = 11, βgal = 9; hFMT-TSHR = 5, βgal = 9; Lab4 TSHR = 11, βgal = 11; vancomycin TSHR = 14, βgal = 4). b Firmicutes to Bacteroidetes ratio comparing immunizations in each timepoint and within each treatment group. Welch’s t test with BH correction: ***P = 0.0006. c Rationale of the SourceTracker analysis (see STAR methods). Human GO donors (n = 6), murine controls (n control/timepoint: baseline = 16, mid = 20, final =20) and hFMT-receiving mice (n hFMT/timepoint: baseline = 15, mid = 24, final = 19). d Pie charts: engraftment expressed as average % probability using the control and the test analysis in each timepoint. Unknown: observations not assigned to a specific source at the significant threshold (a = 0.001)