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Table 1. Microbiota-state time series

From: Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications

DSS

rat

T-7

T-1

T3

T13

T17

T27

T31

T40

T63

T68/75

1

48

1

1

1

1

1

1

nd

2

1

1A

0.25

26

1

1

1

1

1

2

2

2

1

1A

0

17

1

1

1

1

1

2

2

2

1

1A

0.25

21

1

1

1

1

1

1

1

2

1

1A

0

13

1

1

1

1

1

1

1

2

1

1A

0

19

1

1

1

1

1

nd

nd

1

1

1A

0.25

30

1

1

1

2

1

1

nd

1

1

1A

2

56

1

1

1

1

1

1

nd

1

1

1A

1

50

1

1

1

1

1

1

nd

1

1

1A

1

49

1

1

1

1

1

1

nd

1

1

1A

1

45

1

1

1

1

1

1

nd

1

1

1A

0.5

40

2

1

1

1

1

1

nd

1

1

1A

0.5

39

1

1

1

1

1

1

nd

1

1

1A

0

14

1

1

1

1

1

1

nd

1

1

1A

3

11

1

1

1

1

2

1

1

1

1

1A

0.25

28

1

2

2

1

1

1

1

1

1

1A

0

12

2

2

2

1

1

1

1

1

1

1A

0.5

34

1

2

1

1

1

1

1

1

1

1A

2

53

1

1

1

1

1

1

1

1

1

1A

1

46

1

1

1

1

1

1

1

1

1

1A

1

44

1

1

1

1

1

1

1

1

1

1A

0.5

38

1

1

1

1

1

1

1

1

1

1A

0.5

37

1

1

1

1

1

1

1

1

1

1A

0.5

36

1

1

1

1

1

1

1

1

1

1A

0.5

31

1

1

1

1

1

1

1

1

1

1A

0.25

29

1

1

1

1

1

1

1

1

1

1A

0.25

23

1

1

1

1

1

1

1

1

1

1A

0.25

22

1

1

1

1

1

1

1

1

1

1A

0

16

1

1

1

1

1

1

1

1

1

1A

0

15

1

1

1

1

1

1

1

1

1

1A

0

20

1

1

1

1

1

2

nd

2

2

1B

2

58

1

1

1

1

1

2

2

2

1

1B

2

60

1

1

1

1

1

1

nd

1

1

1B

2

54

1

1

1

1

1

2

2

1

1

1B

0.5

33

1

1

1

1

1

1

2

1

1

1B

3

65

1

1

1

1

1

1

1

1

1

1B

3

43

1

1

1

1

1

1

1

1

1

1B

1

42

1

1

1

1

1

1

1

1

1

1B

1

41

1

1

1

1

1

1

1

1

1

1B

3

70

1

1

1

1

1

2

nd

2

2

2A

0

18

2

1

1

1

2

2

2

2

2

2A

0.5

35

1

1

1

1

1

2

2

1

2

2A

2

57

1

1

1

1

1

2

2

2

1

2A

2

59

2

1

1

1

1

1

nd

1

1

2A

0.5

32

1

1

1

1

nd

2

2

1

1

2A

0.25

27

2

2

2

1

1

1

1

1

1

2A

0.25

25

1

2

1

1

1

1

2

1

1

2A

0.25

24

1

1

1

1

1

1

1

1

1

2A

3

64

1

1

1

1

1

nd

2

2

2

2B

3

68

1

1

1

1

1

2

2

2

2

2B

2

52

1

1

1

1

1

2

2

2

2

2B

2

51

1

1

1

1

1

1

2

2

2

2B

3

62

1

1

1

2

2

2

2

1

2

2B

3

69

1

1

1

1

1

1

nd

2

1

2B

3

67

1

1

1

1

1

2

2

2

1

2B

2

55

1

1

1

2

1

1

2

2

1

2B

1

47

2

1

1

1

1

2

2

1

1

2B

3

66

1

1

1

1

1

1

1

1

1

2B

  1. Evolution of microbiota state with time is indicated for individual rats. DSS percentage of DSS used during treatment periods, rat rat number; T-7 to T63, time-points of fecal sampling; T68/75, T68 for fecal sampling and T75 for distal colon inflammatory status evaluation, respectively; 1 basal-state microbiota, 2 (bold script), alternative-state microbiota, nd not determined, A basal host inflammatory state, B alternative host inflammatory state (low-level inflammation). Rats (lines of the table) are grouped according to the host-ecosystem state at T68/75 (last column, cf Fig. 5), then by resemblance of microbiota-by-time profile from T27 onward