Skip to main content

Table 1. Microbiota-state time series

From: Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications

DSS rat T-7 T-1 T3 T13 T17 T27 T31 T40 T63 T68/75
1 48 1 1 1 1 1 1 nd 2 1 1A
0.25 26 1 1 1 1 1 2 2 2 1 1A
0 17 1 1 1 1 1 2 2 2 1 1A
0.25 21 1 1 1 1 1 1 1 2 1 1A
0 13 1 1 1 1 1 1 1 2 1 1A
0 19 1 1 1 1 1 nd nd 1 1 1A
0.25 30 1 1 1 2 1 1 nd 1 1 1A
2 56 1 1 1 1 1 1 nd 1 1 1A
1 50 1 1 1 1 1 1 nd 1 1 1A
1 49 1 1 1 1 1 1 nd 1 1 1A
1 45 1 1 1 1 1 1 nd 1 1 1A
0.5 40 2 1 1 1 1 1 nd 1 1 1A
0.5 39 1 1 1 1 1 1 nd 1 1 1A
0 14 1 1 1 1 1 1 nd 1 1 1A
3 11 1 1 1 1 2 1 1 1 1 1A
0.25 28 1 2 2 1 1 1 1 1 1 1A
0 12 2 2 2 1 1 1 1 1 1 1A
0.5 34 1 2 1 1 1 1 1 1 1 1A
2 53 1 1 1 1 1 1 1 1 1 1A
1 46 1 1 1 1 1 1 1 1 1 1A
1 44 1 1 1 1 1 1 1 1 1 1A
0.5 38 1 1 1 1 1 1 1 1 1 1A
0.5 37 1 1 1 1 1 1 1 1 1 1A
0.5 36 1 1 1 1 1 1 1 1 1 1A
0.5 31 1 1 1 1 1 1 1 1 1 1A
0.25 29 1 1 1 1 1 1 1 1 1 1A
0.25 23 1 1 1 1 1 1 1 1 1 1A
0.25 22 1 1 1 1 1 1 1 1 1 1A
0 16 1 1 1 1 1 1 1 1 1 1A
0 15 1 1 1 1 1 1 1 1 1 1A
0 20 1 1 1 1 1 2 nd 2 2 1B
2 58 1 1 1 1 1 2 2 2 1 1B
2 60 1 1 1 1 1 1 nd 1 1 1B
2 54 1 1 1 1 1 2 2 1 1 1B
0.5 33 1 1 1 1 1 1 2 1 1 1B
3 65 1 1 1 1 1 1 1 1 1 1B
3 43 1 1 1 1 1 1 1 1 1 1B
1 42 1 1 1 1 1 1 1 1 1 1B
1 41 1 1 1 1 1 1 1 1 1 1B
3 70 1 1 1 1 1 2 nd 2 2 2A
0 18 2 1 1 1 2 2 2 2 2 2A
0.5 35 1 1 1 1 1 2 2 1 2 2A
2 57 1 1 1 1 1 2 2 2 1 2A
2 59 2 1 1 1 1 1 nd 1 1 2A
0.5 32 1 1 1 1 nd 2 2 1 1 2A
0.25 27 2 2 2 1 1 1 1 1 1 2A
0.25 25 1 2 1 1 1 1 2 1 1 2A
0.25 24 1 1 1 1 1 1 1 1 1 2A
3 64 1 1 1 1 1 nd 2 2 2 2B
3 68 1 1 1 1 1 2 2 2 2 2B
2 52 1 1 1 1 1 2 2 2 2 2B
2 51 1 1 1 1 1 1 2 2 2 2B
3 62 1 1 1 2 2 2 2 1 2 2B
3 69 1 1 1 1 1 1 nd 2 1 2B
3 67 1 1 1 1 1 2 2 2 1 2B
2 55 1 1 1 2 1 1 2 2 1 2B
1 47 2 1 1 1 1 2 2 1 1 2B
3 66 1 1 1 1 1 1 1 1 1 2B
  1. Evolution of microbiota state with time is indicated for individual rats. DSS percentage of DSS used during treatment periods, rat rat number; T-7 to T63, time-points of fecal sampling; T68/75, T68 for fecal sampling and T75 for distal colon inflammatory status evaluation, respectively; 1 basal-state microbiota, 2 (bold script), alternative-state microbiota, nd not determined, A basal host inflammatory state, B alternative host inflammatory state (low-level inflammation). Rats (lines of the table) are grouped according to the host-ecosystem state at T68/75 (last column, cf Fig. 5), then by resemblance of microbiota-by-time profile from T27 onward