Fig. 5

Gut fungal ecosystems in healthy donors have an impact in systemic anti-commensal response. a Hieratical clustering of the 50 most abundant species in gut mycobiome of healthy donors. This analysis revealed that our healthy population could be shared in two clusters showing two well-differentiated ecosystems (Eco). b Comparison of relative abundances between both ecosystems. Differences were mainly driven by the more abundant fungi, Saccharomyces but also by less abundant fungi such as Cyberlindnera. c Comparison of anti-commensal IgG responses between both ecosystems. Statistical analysis was performed using Mann-Whitney test (**p < 0.05)