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Table 1 Ingenuity pathway analysis (IPA)

From: Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

  Functions annotation P value Activation z-score Molecules # molecules
Cell-to-cell signalling and Interaction, nervous system development and function Synaptic transmission 2.83E−11 − 1.763 AMPH, ANKS1B, CAMK2A, CNP, CPNE6, DLG2, DLG4, DPYSL2, ERC2, FBXO2, GNAI2, HNRNPK, MAPT, NAPA, NPTX1, NRCAM, NSF, PAFAH1B1, PARK7, PPP3CA, PPP3R1, PRKCG, PSMC5, RAB3A, S100B, H3GL2, SLC12A5, SLC1A3, SNAP25, SNPH, SYN1, SYN2, SYNGAP1, UNC13A, VDAC1 35
Behaviour Learning 2.72E−14 − 1.697 ACTG1, AMPH, ATP1A3, CAMK2A, CFL1, CKB, CKMT1A/CKMT1B, CPT1C, CRMP1, CTNND2, DLG3, DLG4, ELAVL4, FBXO2, GMFB, GSK3B, HAPLN1, KCNAB2, MAPT, NCAM1, NCDN, NRAS, NRCAM, NTRK2, PAFAH1B1, PARK7, PDE1B, PEX5L, PPP3CA, PPP3R1, PRKAR1A, PRKAR2B, PRKCG, RTN4, S100B, SHANK1, SLC12A5, SNAP25, SOD2, SRCIN1, SYNGAP1, SYNJ1, SYNPO, TRIM3, TSN, VDAC1 46
Cell-to-cell signalling and interaction, nervous system development and function Neurotransmission 4.44E−12 − 1.656 AMPH, ANKS1B, CAMK2A, CNP, CPNE6, DLG2, DLG4, DNM1, DPYSL2, ERC2, FBXO2, GDAP1, GNAI2, HNRNPK, KCTD12, MAPT, NAPA, Nefm, NPTX1, NRCAM, NSF, NTRK2, PAFAH1B1, PARK7, PPP3CA, PPP3R1, PRKCG, PSMC5, RAB3A, S100B, SH3GL2, SLC12A5, SLC1A3, SNAP25, SNPH, SRCIN1, SYN1, SYN2, SYNGAP1, UNC13A, VDAC1 41
Cell morphology, cellular assembly and organization, nervous system development and function Elongation of neurites 4.27E−08 − 0.228 ALCAM, CAMK2A, DPYSL2, GNAS, MAPT, NTRK2, OMG, PACSIN1, PAFAH1B1, PFN1, PFN2, RAB35 12
Behaviour Locomotion 6.83E−07 − 0.087 ABAT, AGAP2, ATP1A1, ATP1A3, CAMK2A, CNP, DLG3, DLG4, DNM1, ELAVL4, GMFB, HINT1, MAPT, NCAM1, NEFL, NRCAM, NTRK2, OMG, OXR1, PAFAH1B1, PARK7, PDE1B, RTN4, SNAP25, SOD1, SOD2, SPTBN4, TSN 28
  1. Ingenuity pathway analysis (IPA) of the significantly up- and downregulated proteins (after Bonferroni correction) in the hippocampus of young mice transplanted with faeces from aged donors (FMT-aged) versus young mice transplanted with faeces transplant from young age-matched mice (FMT-adult). The enriched categories, related to specific function annotations, the P value, the z-score of the software and the involved proteins are displayed