Table 1 Ingenuity pathway analysis (IPA)

Cell-to-cell signalling and Interaction, nervous system development and function

Synaptic transmission

2.83E−11

− 1.763

AMPH, ANKS1B, CAMK2A, CNP, CPNE6, DLG2, DLG4, DPYSL2, ERC2, FBXO2, GNAI2, HNRNPK, MAPT, NAPA, NPTX1, NRCAM, NSF, PAFAH1B1, PARK7, PPP3CA, PPP3R1, PRKCG, PSMC5, RAB3A, S100B, H3GL2, SLC12A5, SLC1A3, SNAP25, SNPH, SYN1, SYN2, SYNGAP1, UNC13A, VDAC1

35

Behaviour

Learning

2.72E−14

− 1.697

ACTG1, AMPH, ATP1A3, CAMK2A, CFL1, CKB, CKMT1A/CKMT1B, CPT1C, CRMP1, CTNND2, DLG3, DLG4, ELAVL4, FBXO2, GMFB, GSK3B, HAPLN1, KCNAB2, MAPT, NCAM1, NCDN, NRAS, NRCAM, NTRK2, PAFAH1B1, PARK7, PDE1B, PEX5L, PPP3CA, PPP3R1, PRKAR1A, PRKAR2B, PRKCG, RTN4, S100B, SHANK1, SLC12A5, SNAP25, SOD2, SRCIN1, SYNGAP1, SYNJ1, SYNPO, TRIM3, TSN, VDAC1

46

Cell-to-cell signalling and interaction, nervous system development and function

Neurotransmission

4.44E−12

− 1.656

AMPH, ANKS1B, CAMK2A, CNP, CPNE6, DLG2, DLG4, DNM1, DPYSL2, ERC2, FBXO2, GDAP1, GNAI2, HNRNPK, KCTD12, MAPT, NAPA, Nefm, NPTX1, NRCAM, NSF, NTRK2, PAFAH1B1, PARK7, PPP3CA, PPP3R1, PRKCG, PSMC5, RAB3A, S100B, SH3GL2, SLC12A5, SLC1A3, SNAP25, SNPH, SRCIN1, SYN1, SYN2, SYNGAP1, UNC13A, VDAC1

41

Cell morphology, cellular assembly and organization, nervous system development and function

Elongation of neurites

4.27E−08

− 0.228

ALCAM, CAMK2A, DPYSL2, GNAS, MAPT, NTRK2, OMG, PACSIN1, PAFAH1B1, PFN1, PFN2, RAB35

12

Behaviour

Locomotion

6.83E−07

− 0.087

ABAT, AGAP2, ATP1A1, ATP1A3, CAMK2A, CNP, DLG3, DLG4, DNM1, ELAVL4, GMFB, HINT1, MAPT, NCAM1, NEFL, NRCAM, NTRK2, OMG, OXR1, PAFAH1B1, PARK7, PDE1B, RTN4, SNAP25, SOD1, SOD2, SPTBN4, TSN

28