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Fig. 10 | Microbiome

Fig. 10

From: Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

Fig. 10

Post-FMT levels of GFAP and F4/80 in hippocampal areas. Representative images acquired at the confocal microscope with anti-GFAP antibody (green) and the relevant fluorescent intensity in different areas of the hippocampus (ah). No difference was observed between FMT-adult (left panels a, d and g) and FMT-aged (middle panels b, e and h) in the expression of GFAP. The analysis was carried out in the dentate gyrus region (a, b, fluorescent intensity shown in c), CA4 region (d, e, fluorescent intensity shown in f) and CA3 region (gI, fluorescent intensity shown in i). By contrast, a significant increase of the expression of F4/80 (red) (j, k, fluorescent intensity shown in l) was observed in the white matter of the hippocampus fimbria between FMT-adult (j) and FMT-aged mice (k). The detail of the hippocampus regions investigated are displayed in Additional File 13. Fluorescence intensity bars represent the mean ± SEM from 3 mice/group and asterisk indicates P = 0.0168. Nuclei have been counterstained with ToPro-3 (in blue). (scale bars 30 μm)

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