Fig. 3

Gut bacterial ClpB-like gene function and metagenomics. a Top bacterial taxa at the family level contributing reads to the gut bacterial ClpB-like gene function, in total relative figures per sample (uncultured, uc; not assigned, na). b–d Box plots showing the differences of some of the top ten bacterial families (relative abundance, RA) contributing to the gut bacterial ClpB-like gene function in subjects with and without obesity. e Mice body weights after gut microbiota transplantation. Controls (mouse, M; control, c) are shown in yellow (n = 11) and mice which received microbiota from human donors (transplant, t) are shown in blue (n = 22). f Bar chart showing mean and standard deviation mice body weights, regarding the median of the gut bacterial ClpB-like gene function detected in mice, K03695 (arbitrary units, AU). g Scatterplot showing the relationship between percent weight gain in mice (calculated as (body weight final (g)—body weight initial (g))/body weight initial (g)*100) and gut bacterial ClpB-like gene function, K03695 (AU), in mice. h Scatterplot showing the relationship between percent weight gain in mice and Prevotellaceae RA in humans. i Scatterplot showing the relationship between gut bacterial ClpB-like gene function (K03695, KEGG annotation) and Prevotellaceae absolute abundance (AA) in mice. j Scatterplot showing the relationship between the final weight (7th week) in mice and Prevotellaceae baroniae AA in humans. k Scatterplot showing the relationship between gut bacterial ClpB-like gene function (K03695, KEGG annotation) in mice and Prevotellaceae baroniae AA in human donors