Fig. 6

IL-6 knockout protects against inflammation induced by Treg depletion in mice. a Representative dot plots showing Foxp3 expression on splenic CD4+ T cells on day 14 post-injection with IgG and CD25 antibody (αCD25) in WT and IL-6^−/− mice (n = 6–8). b The percentage of splenic CD4+ Foxp3+ T regulatory cells on day 14 post-injection with IgG and αCD25 in WT and IL-6^−/− mice (n = 6–8). c Representative H&E staining of liver and lung from WT and IL-6^−/− mice with IgG or αCD25 treatment (n = 6–8). d Quantitation of inflammatory infiltrates in the liver and lung of WT and IL-6^−/− mice with IgG or αCD25 treatment (n = 6–8). e Plasma levels of IL-6, IL-10, and IL-2 in WT and IL-6^−/− mice with IgG or αCD25 treatment (n = 6–8). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001