Fig. 2
From: Identification and reconstruction of novel antibiotic resistance genes from metagenomes
a–f Results from optimization of six ARG models for the four classes of β-lactamases. Each figure shows the performance of correctly classifying fragments as ARGs. The green curve shows the sensitivity, i.e. the fraction of correctly classified fragments from true resistance genes, while the orange curve shows 1-specificity, i.e. the fraction of incorrectly fragment sequences from genes without a resistance phenotype. A model with good performance should have a high sensitivity while 1-specificity should be low. The dashed line corresponds to the model threshold selected to have a high sensitivity and an acceptable specificity