Fig. 2
From: Systemic translocation of Staphylococcus drives autoantibody production in HIV disease
Gene expression profiles of purified B cells from HIV+ subjects with high ANA compared to low ANA production in response to influenza vaccination. The comparisons were analyzed by the ratios of gene expression in sorted total B cells from HIV+ high ANA (n = 5) vs low ANA (n = 9) subjects on D0 and D7 post-vaccination. a Heat map of fold changes in gene expression. Genes with similar patterns were grouped by clustering analysis (indicated by color bars on the left) and represented coherently changed genes in the clusters. b Representative immunological pathways enriched in coherently changed genes in HIV+ high ANA compared to low ANA subjects. c Expression of various gene encoding products in selected pathways showing increased (red) or decreased (blue) expression in HIV+ high ANA compared to low ANA subjects