Fig. 3
From: Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome
a Molecular networks of peptides and amino acids that strongly separated the two metabolomic clusters. Each node represents a consensus MS/MS spectrum and edges between the nodes represent spectral similarity as determined by the cosine score. The pie chart inside the nodes shows the number of spectra found in each cluster. Nodes with blue a green outline were annotated from GNPS MS/MS library searching and those with a blue outline were identified in the random forest variable importance plot. Notch plots of the MS1 normalized abundance of nodes of interest as well as the entire peptide networks are shown and the Mann-Whitney U test was used to determine significance. b Frequency rank plot of amino acid abundances in the de novo peptide sequencing data