Table 10 Genes differentially expressed in skin T effector cells of SPF + SA-colonized mice vs. SPF-colonized mice

Adgrl4

1.11E−21

7.51E−19

Efnb2

1.30E−20

7.82E−18

Ptprb

2.57E−16

5.87E−14

Sele

6.20E−10

2.94E−08

Procr

7.75E−12

6.08E−10

Il17a

5.36E−27

1.29E−23

Galnt15

7.57E−20

3.87E−17

Cyyr1

2.11E−18

7.90E−16

Rgs4

2.77E−20

1.51E−17

Flt1

4.15E−17

1.17E−14

Btnl9

1.83E−17

5.72E−15

Nts

1.35E−13

1.72E−11

Lamb2

2.31E−16

5.41E−14

Car4

1.67E−18

6.41E−16

Lss

5.12E−12

4.30E−10

Blk

1.17E−09

5.16E−08

RP24-360B3.1

1.60E−16

4.02E−14

Tinagl1

4.26E−19

1.85E−16

Stc1

1.80E−12

1.69E−10

Me1

2.90E−15

5.20E−13

Aqp7

2.58E−12

2.27E−10

Ptprm

1.62E−17

5.16E−15

Rasip1

1.87E−12

1.73E−10

Itga7

4.83E−15

8.40E−13

Rbp7

5.20E−09

1.99E−07

Selp

7.89E−12

6.13E−10

Il17f

2.25E−14

3.42E−12

Angpt2

2.37E−12

2.14E−10

Hid1

3.39E−17

1.00E−14

Adamts9

7.13E−16

1.43E−13

Sqle

2.08E−13

2.51E−11

Pdgfb

7.58E−12

5.98E−10

Gpihbp1

1.07E−16

2.77E−14

Galnt18

4.46E−17

1.23E−14

Sned1

3.86E−13

4.37E−11

Sulf1

6.17E−16

1.29E−13

Lamc3

1.44E−10

7.91E−09

Stap2

8.80E−19

3.62E−16

Ccm2l

2.11E−14

3.27E−12

Tnc

2.22E−12

2.03E−10

Esrp1

7.74E−10

3.56E−08

Cyp17a1

2.27E−08

7.07E−07

Nrip2

1.06E−16

2.77E−14

Alas2

4.62E−13

5.13E−11

Aadac

7.90E−08

2.09E−06

Unc45b

3.29E−11

2.14E−09

Enpp4

5.32E−13

5.72E−11

Pappa2

4.75E−12

4.05E−10

Tcrg-C4

6.93E−14

9.59E−12

Bcam

2.25E−13

2.67E−11

Tie1

7.30E−12

5.78E−10

Gja5

2.45E−10

1.28E−08

Rassf9

1.20E−14

1.97E−12

Tfap2c

6.73E−16

1.37E−13

Gdap10

1.67E−16

4.16E−14

Ppm1l

7.46E−14

1.02E−11

Ptch2

1.15E−12

1.15E−10

Vtn

6.14E−12

5.01E−10

Dll4

3.19E−14

4.67E−12

Fam73a

1.17E−13

1.53E−11

Pcdh17

2.72E−14

4.10E−12

Ptgs1

8.06E−12

6.24E−10

Slc12a1

1.88E−14

2.96E−12

Gm37297

4.01E−16

8.79E−14

Cyp1a1

5.32E−08

1.49E−06

Shroom4

1.35E−09

5.84E−08

Gm12158

1.18E−13

1.53E−11

Ackr3

2.01E−16

4.86E−14

Clstn3

7.71E−11

4.57E−09

Hmcn1

6.27E−16

1.29E−13

Tek

3.10E−19

1.46E−16

Esrp2

6.62E−11

3.98E−09

Ednra

4.06E−08

1.18E−06

Thsd7a

3.99E−10

2.01E−08

Tdrd9

1.23E−08

4.19E−07

Sfrp1

1.80E−10

9.60E−09

Aplnr

1.46E−17

4.83E−15

Mall

1.20E−14

1.97E−12

Mx2

2.10E−13

2.51E−11

Snca

7.99E−08

2.11E−06

Gm15740

4.67E−14

6.73E−12

Sectm1b

6.10E−15

1.05E−12

Tacr1

1.24E−07

3.06E−06

Rapgef5

1.49E−14

2.42E−12

Clec1a

5.45E−07

1.10E−05

Prox1

1.31E−09

5.71E−08

Clec14a

7.87E−08

2.09E−06

Rasgrf2

5.56E−12

4.62E−10

Dll1

1.93E−15

3.62E−13

Stac2

8.92E−12

6.70E−10

Celsr2

1.88E−11

1.27E−09

Robo1

1.30E−10

7.27E−09

Cxadr

7.82E−12

6.11E−10

Clic5

7.72E−09

2.82E−07

Taf9b

4.11E−14

5.98E−12

Spns2

2.74E−12

2.38E−10

Dhcr24

2.55E−13

2.94E−11

Gm37736

2.18E−14

3.34E−12

Gm16587

5.16E−07

1.05E−05

Ret

2.75E−08

8.36E−07

Tmem45b

1.37E−06

2.44E−05

Il22

1.82E−12

1.70E−10

Upp1

1.49E−13

1.88E−11

Paqr5

8.56E−10

3.84E−08

Piezo2

1.23E−10

6.96E−09

Psd2

5.60E−10

2.76E−08

Adtrp

4.97E−08

1.41E−06

Gk5

1.43E−07

3.46E−06

Cldn15

6.11E−11

3.73E−09

Aqp1

1.51E−13

1.90E−11

Heph

7.85E−13

8.13E−11

Emilin1

1.81E−15

3.44E−13

Plxna4

2.32E−09

9.56E−08

Ano1

7.20E−09

2.67E−07

Ebf3

2.28E−12

2.07E−10

Sgip1

3.58E−10

1.82E−08

Gm38125

4.44E−11

2.83E−09

Avpr1a

9.93E−08

2.55E−06

Tcrg-V6

7.86E−10

3.57E−08

Hoxd10

5.26E−14

7.46E−12

Dchs1

1.14E−13

1.51E−11

Hrct1

1.07E−08

3.74E−07

C1qtnf9

3.45E−17

1.00E−14

Lrg1

1.31E−15

2.55E−13

Fgfbp1

1.99E−07

4.60E−06

Eps8l2

5.95E−12

4.87E−10

RP24-188E19.4

6.55E−11

3.95E−09

Vsig10

4.56E−09

1.76E−07

Exd2

2.86E−14

4.28E−12

Rnd1

2.14E−10

1.13E−08

Adgrg6

4.55E−11

2.88E−09

Adcy4

1.40E−10

7.73E−09

Cyp2b19

2.24E−07

5.05E−06

Ndst3

1.94E−09

8.13E−08

Xlr4c

9.66E−13

9.82E−11

RP24-188E19.3

6.41E−13

6.76E−11

Stc2

2.37E−08

7.35E−07

Lmbr1

2.35E−07

5.24E−06

2610012C04Rik

3.39E−11

2.19E−09

Yes1

9.29E−09

3.32E−07

Sgcb

4.81E−08

1.37E−06

Vsig2

7.85E−08

2.09E−06

Zfpm2

9.96E−12

7.37E−10

Oaf

1.97E−07

4.55E−06

Sybu

1.23E−09

5.41E−08

Ebf2

2.05E−14

3.20E−12

Gm26667

1.06E−13

1.42E−11

Abca5

4.10E−08

1.19E−06

Lrat

9.53E−11

5.53E−09

Slc2a4

4.08E−09

1.59E−07

Zfp532

8.47E−12

6.47E−10

Grrp1

2.00E−11

1.34E−09

Slc2a13

5.70E−12

4.69E−10

Gm37783

1.95E−13

2.39E−11

Fat4

1.54E−09

6.59E−08

Slc33a1

1.77E−11

1.20E−09

Gtf2h2

1.32E−10

7.39E−09

C130079G13Rik

5.71E−06

8.18E−05

Col6a6

2.41E−12

2.16E−10

Adamtsl1

6.25E−07

1.23E−05

Pcdh12

2.24E−08

6.99E−07

Npy1r

1.53E−11

1.06E−09

Tfap2a

1.39E−06

2.47E−05

Gm38157

7.45E−10

3.47E−08

RP24-194 J1.1

4.42E−07

9.16E−06

Adgrf5

4.35E−24

4.89E−21

Sumf2

4.48E−08

1.28E−06

Moxd1

1.56E−10

8.50E−09

Fdxr

3.58E−09

1.41E−07

Colec11

6.02E−10

2.87E−08

St6galnac5

6.51E−10

3.06E−08

Pparg

3.72E−08

1.10E−06

Ndnf

5.09E−10

2.53E−08

Gm15712

3.20E−12

2.77E−10

Tcaf2

7.47E−08

2.00E−06

Adam12

1.98E−07

4.57E−06

Vstm4

1.24E−06

2.23E−05

Pkn3

2.55E−08

7.88E−07

RP23-363 M4.2

8.36E−12

6.41E−10

Neurl1b

5.73E−07

1.14E−05

4631405K08Rik

6.73E−13

7.01E−11

Dennd2c

1.57E−08

5.17E−07

Il23r

3.27E−12

2.82E−10

Cda

1.11E−08

3.84E−07

Higd1b

2.23E−06

3.63E−05

Plscr2

1.11E−06

2.03E−05

Lcn2

4.39E−10

2.21E−08

Lrrn1

5.24E−08

1.48E−06

Nipsnap1

3.79E−06

5.75E−05

Zfp57

9.44E−13

9.65E−11

Reep6

2.48E−07

5.51E−06

Dach1

5.34E−07

1.08E−05

Cpa6

1.47E−11

1.04E−09

Scube1

1.49E−07

3.58E−06

Tmem51

5.87E−10

2.82E−08

Prlr

5.71E−11

3.52E−09

Nova2

4.46E−07

9.23E−06

Arnt2

1.01E−07

2.59E−06

Cldn5

8.94E−12

6.70E−10

Slc6a17

4.66E−09

1.79E−07

Gucy1b3

1.90E−07

4.42E−06

Nrbp2

5.74E−06

8.20E−05

Fgfrl1

5.81E−10

2.80E−08

Fam13c

2.88E−06

4.53E−05

RP24-95O4.6

2.13E−06

3.50E−05

Apmap

9.28E−09

3.32E−07

Crygd

3.17E−04

2.36E−03

Gdf10

1.43E−08

4.75E−07

Plxnb1

4.34E−08

1.25E−06

Foxc1

3.07E−11

2.00E−09

Has1

3.76E−19

1.67E−16

Hs3st1

8.06E−07

1.53E−05

Ppp1r3c

1.84E−07

4.33E−06

Dio2

7.06E−08

1.92E−06

Gjc3

1.04E−07

2.65E−06

Jmjd8

5.71E−10

2.80E−08

RP23-378O9.1

7.83E−09

2.85E−07

Zfp212

1.91E−07

4.45E−06

Acvr1

4.06E−07

8.51E−06

Zdhhc15

8.13E−10

3.68E−08

Lamb3

6.23E−09

2.34E−07

Slc26a7

5.24E−06

7.60E−05

Itgb4

7.00E−06

9.67E−05

Tmem56

1.33E−06

2.39E−05

Mtrr

9.62E−12

7.15E−10

Gm12122

3.62E−10

1.84E−08

Epas1

2.23E−17

6.86E−15

Vldlr

7.75E−07

1.48E−05

Ifitm5

2.02E−13

2.45E−11

Fam135a

3.93E−13

4.43E−11

Kcne4

1.98E−06

3.31E−05

Sort1

3.14E−07

6.84E−06

Mir1192

3.55E−10

1.81E−08

Pigl

7.32E−09

2.70E−07

Smoc1

1.09E−07

2.75E−06

Lrrc8b

7.78E−10

3.56E−08

Gm17096

7.74E−10

3.56E−08

Gm37524

2.42E−09

9.93E−08

Per3

9.01E−18

3.10E−15

Pvrl2

1.86E−07

4.36E−06

Adra2a

2.48E−08

7.66E−07

Plod2

2.98E−15

5.30E−13

Cryba4

3.26E−06

5.04E−05

RP24-360B3.3

1.33E−07

3.24E−06

Kcnj2

1.46E−07

3.52E−06

Tnfsf10

5.49E−09

2.09E−07

Pcdhga8_dup1

2.10E−07

4.79E−06

Ifi44

6.99E−06

9.67E−05

Adck1

6.01E−08

1.65E−06

Supv3l1

2.95E−09

1.18E−07

Pawr

6.18E−11

3.76E−09

Osmr

1.32E−08

4.43E−07

Derl3

8.50E−10

3.83E−08

RP24-188E19.2

1.62E−07

3.84E−06

Gm11730

6.43E−11

3.90E−09

B230216N24Rik

7.29E−09

2.69E−07

Pou2f3

2.87E−09

1.15E−07

Fam161b

1.10E−07

2.78E−06

Chchd10

6.25E−10

2.95E−08

Miat

2.21E−07

4.99E−06

Nr6a1

1.10E−08

3.82E−07

Clnk

3.53E−10

1.81E−08

RP24-303G10.1

2.05E−08

6.56E−07

Exoc3l2

1.41E−06

2.50E−05

Gm15609

5.80E−10

2.80E−08

Gm17477

6.01E−11

3.69E−09

Egfl8

1.56E−11

1.08E−09

Pcdhb17

1.01E−07

2.59E−06

Shb

2.08E−08

6.63E−07

Il7

8.04E−11

4.75E−09

Slc1a3

3.99E−06

6.04E−05

Ntrk3

4.16E−07

8.66E−06

Gypa

4.66E−06

6.85E−05

Tmem255b

2.10E−05

2.44E−04

Tgfa

5.81E−10

2.80E−08

6430590A07Rik

9.61E−10

4.28E−08

Ltbp2

2.02E−07

4.65E−06

Gm17491

3.53E−07

7.55E−06

4-Sep

1.00E−23

9.51E−21

Mboat2

1.44E−07

3.50E−06

Tle2

1.11E−08

3.84E−07

Gjb3

2.70E−05

3.01E−04

Rassf10

1.73E−08

5.62E−07

Dnm3os

2.43E−12

2.16E−10

Tenm4

6.98E−09

2.60E−07

D630008O14Rik

4.49E−06

6.65E−05

Enpp3

6.18E−09

2.32E−07

Kcna2

9.09E−07

1.71E−05

Gm15844

2.84E−05

3.12E−04

Tor4a

1.53E−06

2.67E−05

Trp63

1.37E−12

1.33E−10

Myo1d

1.02E−05

1.34E−04

Ctif

6.62E−12

5.34E−10

Calm4

1.18E−05

1.51E−04

Serpinb1c

8.28E−08

2.17E−06

RP24-421E18.7

6.27E−12

5.09E−10

Dgkh

8.78E−12

6.65E−10

Bnc2

3.63E−11

2.34E−09

Pfkfb2

1.28E−08

4.31E−07

Pcdh9

1.06E−07

2.69E−06

Abca12

1.07E−06

1.97E−05

Fzd4

8.16E−09

2.96E−07

Csrnp2

1.68E−08

5.49E−07

Cds1

2.64E−09

1.07E−07

Tnn

1.54E−05

1.89E−04

Kcna5

1.78E−09

7.56E−08

Fermt1

9.76E−07

1.82E−05

Comp

3.31E−08

9.89E−07

Pkp1

1.93E−09

8.11E−08

Hephl1

6.29E−06

8.88E−05

Nxpe4

2.67E−09

1.08E−07

Prkd1

1.70E−06

2.91E−05

Gm7162

3.33E−09

1.32E−07

Tfap2b

2.37E−07

5.28E−06

RP24-496C22.5

2.49E−09

1.01E−07

Ptprr

3.74E−05

3.95E−04

Cacna1c

9.05E−10

4.04E−08

Fam57b

3.82E−09

1.50E−07

RP24-360B3.2

1.88E−12

1.73E−10

Gtf2ird1

2.43E−11

1.62E−09

Tnfrsf22

2.04E−10

1.08E−08

P3h1

1.23E−07

3.03E−06

3110001I22Rik

5.23E−07

1.06E−05

Dmpk

5.10E−13

5.52E−11

Tmem41a

1.01E−11

7.44E−10

Hoxa5

2.15E−07

4.88E−06

Myocd

3.07E−08

9.24E−07

Ackr1

1.04E−11

7.65E−10

Sox6

1.95E−06

3.27E−05

Schip1_dup1

7.42E−08

1.99E−06

Tc2n

3.43E−09

1.36E−07

Ptpn14

5.58E−10

2.76E−08

Zglp1

9.16E−08

2.37E−06

Trmt11

1.62E−09

6.91E−08

C2cd2l

2.57E−08

7.91E−07

RP23-333I5.3

3.72E−06

5.67E−05

Pkhd1l1

1.13E−07

2.85E−06

Nxpe2

6.37E−07

1.25E−05

Tex15

6.48E−08

1.77E−06

Syt7

2.03E−08

6.49E−07

Mmgt2

1.85E−08

5.96E−07

AI838599

1.20E−07

2.97E−06

Prr9

2.11E−05

2.45E−04

Srd5a3

1.54E−09

6.59E−08

Slc35f1

5.82E−09

2.20E−07

Tmtc4

1.67E−05

2.01E−04

Cyp2e1

9.70E−07

1.81E−05

RP23-157G2.2

2.86E−08

8.66E−07

Plin4

4.95E−08

1.40E−06

Heatr5b

7.49E−09

2.76E−07

Lhx6

2.28E−05

2.62E−04

Ccdc85a

6.36E−08

1.74E−06

RP23-463H10.1

1.18E−06

2.15E−05

RP23-465A17.7

5.93E−08

1.64E−06

Pof1b

5.35E−06

7.75E−05

Vwa3a

1.65E−05

2.00E−04

Rhbdd2

6.07E−10

2.89E−08

Zfp94

2.52E−09

1.03E−07

Zp1

6.28E−07

1.23E−05

Gm38142

1.79E−08

5.80E−07

Fam174b

6.66E−12

5.35E−10

Gm37399

7.40E−07

1.42E−05

Lrig3

1.02E−08

3.60E−07

Tcea2

1.89E−06

3.18E−05

Gm20696

1.01E−05

1.32E−04

Sfxn4

5.76E−10

2.80E−08

Prom1

8.89E−06

1.19E−04

Has2

2.20E−08

6.92E−07

Mamstr

3.33E−08

9.93E−07

Cadps2

2.57E−07

5.68E−06

Fignl2

3.52E−09

1.39E−07

Il17rd

1.77E−10

9.49E−09

Susd4

7.03E−07

1.36E−05

Spock1

3.04E−06

4.75E−05

Ptger2

6.56E−07

1.28E−05

Nudt12

9.58E−07

1.79E−05

Frem2

1.84E−06

3.11E−05

Wfdc3

1.05E−05

1.37E−04

Gpr4

3.49E−05

3.72E−04

Akap6

2.24E−06

3.65E−05

Gprasp2

1.27E−08

4.30E−07

Sncaip

2.29E−05

2.63E−04

Prkab1

7.89E−24

8.32E−21

Gm37780

1.17E−05

1.50E−04

Unc5c

2.23E−07

5.03E−06

Gm37648

2.13E−06

3.50E−05

Gkn3

4.75E−05

4.83E−04

St6galnac2

4.03E−05

4.21E−04

Klhl23

2.90E−08

8.78E−07

Olfr78

3.25E−07

7.05E−06

RP24-247A21.1

2.02E−05

2.36E−04

Dos

1.49E−11

1.05E−09

Scn3a

6.89E−11

4.11E−09

Jade3

3.68E−06

5.62E−05

Fam110b

4.07E−06

6.12E−05

4930578C19Rik

4.64E−06

6.82E−05

Tmed8

1.87E−07

4.37E−06

Hdhd3

1.83E−09

7.76E−08

RP24-147H20.3

7.10E−05

6.78E−04

Adamts20

1.81E−05

2.15E−04

B3gnt3

4.03E−07

8.49E−06

Mal2

3.77E−05

3.98E−04

Tmem41b

1.44E−16

3.69E−14

Efhd1

1.47E−06

2.60E−05

Glce

2.49E−06

3.99E−05

Rragd

7.09E−06

9.80E−05

Vipr2

6.53E−06

9.15E−05

Htr7

8.62E−07

1.63E−05

Hbb-bt

2.48E−15

4.56E−13

Wipf3

1.35E−06

2.41E−05

Gm14085

3.05E−10

1.58E−08

AI846148

2.64E−06

4.18E−05

Unc13b

1.05E−07

2.68E−06

Gm37519

6.67E−09

2.49E−07

Dnah6

1.82E−06

3.09E−05

Zdbf2

3.06E−06

4.78E−05

Chodl

4.73E−05

4.81E−04

Tbc1d19

4.07E−06

6.12E−05

Aoc3

5.53E−07

1.11E−05

Lgr6

5.73E−06

8.18E−05

Prss36

3.98E−08

1.17E−06

Zcchc18

1.70E−05

2.04E−04

Ak4

3.57E−05

3.80E−04

Pde4c

1.04E−07

2.66E−06

Ring1

7.44E−10

3.47E−08

Kcnb1

1.15E−07

2.88E−06

Rergl

7.72E−05

7.24E−04

Ccdc67

3.42E−07

7.34E−06

Ptx3

2.26E−06

3.66E−05

Cc2d2a

4.84E−10

2.42E−08

Efcab7

9.20E−06

1.23E−04

Gm436

1.19E−04

1.03E−03

Srd5a1

6.83E−07

1.32E−05

Stac

3.77E−06

5.74E−05

Pbld2

5.53E−07

1.11E−05

Atoh8

1.55E−06

2.69E−05

Dhrs13

1.26E−08

4.27E−07

Hoxb7

1.20E−06

2.17E−05

Cox18

1.50E−10

8.21E−09

B430010I23Rik

5.76E−10

2.80E−08

Acaa1b

5.23E−07

1.06E−05

Micall2

3.92E−06

5.94E−05

Galns

2.87E−06

4.51E−05

RP24-496C22.2

8.04E−06

1.10E−04

Armcx5

7.69E−11

4.57E−09

Sox17

5.06E−07

1.04E−05

Tmem110

5.65E−14

7.88E−12

C130023A14Rik

2.61E−11

1.71E−09

RP23-293 K21.1

1.65E−06

2.84E−05

Cx3cl1

6.88E−08

1.87E−06

Atat1

5.25E−05

5.25E−04

Dsg2

3.85E−07

8.13E−06

Aldh1a7

1.04E−04

9.22E−04

Zfp69

2.09E−06

3.45E−05

Myh14

6.81E−07

1.32E−05

Afap1l1

3.18E−26

5.97E−23

Mpzl2

6.86E−06

9.54E−05

Flywch2

2.73E−08

8.32E−07

Krtcap3

2.53E−05

2.86E−04

Epb4.1l4b

1.30E−05

1.64E−04

Ficd

3.45E−06

5.31E−05

Sh3gl3

4.95E−06

7.21E−05

Cyb561

2.01E−06

3.35E−05

Gm7909

1.84E−07

4.31E−06

Erf

2.74E−08

8.34E−07

Scgb3a1

8.59E−07

1.62E−05

Cwh43

4.37E−08

1.25E−06

Tfap2e

5.73E−08

1.59E−06

Pou6f1

4.56E−06

6.72E−05

Plxna2

6.16E−20

3.25E−17

Fstl4

4.96E−08

1.40E−06

Lmln

4.34E−08

1.25E−06

RP24-560A18.1

3.62E−06

5.55E−05

Prkg1

4.28E−06

6.38E−05

RP24-399A15.2

2.45E−05

2.79E−04

Cspg4

1.05E−12

1.06E−10

Tmem86a

1.88E−05

2.22E−04

Tll1

5.08E−05

5.11E−04

Laptm4b

7.70E−09

2.82E−07

6430573F11Rik

5.68E−07

1.13E−05

Gm26603

1.02E−07

2.61E−06

Ptk7

8.48E−08

2.22E−06

Igsf9

8.54E−06

1.15E−04

RP23-372C7.4

2.73E−05

3.04E−04

Nol4l

4.88E−08

1.39E−06

Slc7a2

1.20E−11

8.69E−10

Zfp52

2.22E−05

2.56E−04

A730049H05Rik

2.35E−05

2.69E−04

Yars2

8.91E−08

2.32E−06

Mc5r

6.54E−05

6.31E−04

Gm20699

1.54E−08

5.07E−07

4933407K13Rik

1.15E−04

1.00E−03

Tbc1d8

2.86E−18

1.03E−15

Gm9917

7.64E−09

2.80E−07

Aplp1

5.73E−06

8.18E−05

4933416E03Rik

7.80E−04

4.99E−03

Nfatc4

2.59E−11

1.70E−09

Cpeb1

2.24E−08

6.99E−07

Bahcc1

8.17E−07

1.55E−05

Scarb1

3.98E−17

1.14E−14