Fig. 2

Modulation of hepatic lipid profiles. a Liver to body weight ratio. b Triglyceride content. c Amounts, composition, and distribution of total fatty acids measured in fasted mice (n = 4–7 as indicated in the figure). d Alterations in lipid classes and species. Only lipids representing > 1% total amounts were considered for statistical analysis. Color code is as in Fig. 1. SAFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids, unsat unsaturated fatty acids, PC phosphatidylcholine, CE cholesteryl esters. See the “Methods” section for description of mass spectrometric measurements and for statistical analyses. e mRNA relative expression of Cd36 in the liver of mice. GAPDH was used as housekeeping gene for the normalization. GF mice fed the PHB diet were used as reference group. In all figure panels, stars indicate statistical significance as follows: *p < 0.05; **p < 0.01; ***p < 0.001 (two-way ANOVA followed by Holm-Sidak)