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Table 3 Taxa related to alcohol drinking level in all study participants. The association between taxonomic abundance and alcohol drinking level was detected by DESeq function, adjusted for age, sex, race, BMI, education, smoking status, and study

From: Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults

Taxon Class;Order;Family;Genus;Species Mean counts Fold change (95% CI)   
Non-drinkers Moderate drinkers Heavy drinkers Moderate vs. non-drinkers Heavy vs. non-drinkers p trend q trend§
Phylum Firmicutes
Bacilli 5986.51 5578.79 5459.46 0.94 (0.89, 0.98) 0.92 (0.86, 0.98) 0.0055 0.050
Bacilli;Lactobacillales 5687.89 5340.36 5111.72 0.94 (0.88, 1.00) 0.89 (0.82, 0.97) 0.0050 0.064
Bacilli;Lactobacillaes;Streptococcaceae;Streptococcus_gid_304 37.39 181.57 58.55 2.13 (1.66, 2.74) 1.44 (1.03, 2.00) < 0.001 0.015
Bacilli;Lactobacillales;Carnobacteriaceae;Granulicatella;Adiacens_gid_296 133.08 110.70 105.93 0.84 (0.76, 0.93) 0.80 (0.70, 0.92) < 0.001 0.057
Bacilli;Lactobacillales;Carnobacteriaceae;Granulicatella;Elegans_gid_337 15.86 23.52 22.88 1.54 (1.16, 2.04) 1.74 (1.22, 2.48) 0.0013 0.057
Clostridia;Clostridiales;Lachnospiraceae[14];Lachnoanaerobaculum_gid_046 16.1 16.45 25.01 1.05 (0.86, 1.28) 1.52 (1.16, 1.99) 0.0063 0.042
Phylum Bacteroidetes
Bacteroides;Bacteroidales;Bacteroidales[F-2];Bacteroidales[G-2]|| 3.31 7.05 6.94 1.74 (1.30, 2.33) 2.08 (1.43, 3.03) < 0.0001 0.0027
Bacteroides;Bacteroidales;Bacteroidales[F-2];Bacteroidales[G-2];taxon 274_gid_156 1.64 2.43 2.59 1.42 (1.09, 1.83) 1.56 (1.13, 2.17) 0.0043 0.094
Bacteroides;Bacteroidales;Porphyromonadaceae;Tannerella_gid_164 2.28 3.00 3.61 1.28 (0.98, 1.67) 1.60 (1.13, 2.27) 0.0070 0.042
Bacteroides;Bacteroidales;Prevotellaceae;Prevotella_gid_168 1.73 43.72 1.98 2.31 (1.64, 3.25) 1.91 (1.24, 2.94) < 0.001 0.0099
Flavobacterial;Flavobacteriales;Flavobacteriaceae;Bergeyella 3.62 4.62 5.29 1.29 (1.09, 1.54) 1.46 (1.15, 1.84) < 0.001 0.014
Phylum Actinobacteria
Actinobacteria;Actinomycetale;Actinomycetaceae;Actinomyces 103.79 123.63 131.63 1.15 (0.97, 1.37) 1.41 (1.11, 1.78) 0.0047 0.041
Actinobacteria;Actinomycetale;Actinomycetaceae;Actinomyces;Graevenitzii_gid_484 37.25 47.59 55.77 1.17 (0.95, 1.45) 1.53 (1.16, 2.02) 0.0030 0.088
Actinobacteria;Actinomycetales;Corynebacteriaceae;Corynebacterium 21.93 28.95 29.51 1.35 (1.12, 1.63) 1.36 (1.06, 1.76) 0.0064 0.042
Phylum Fusobacteria
Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium_gid_114 184.52 369.96 229.27 1.48 (1.24, 1.78) 1.22 (0.95, 1.56) 0.018 0.090
Fusobacteria;Fusobacteriales;Leptotrichiacefaae;Leptotrichia 70.25 94.78 157.05 1.24 (1.05, 1.48) 1.61 (1.27, 2.03) < 0.0001 0.0027
Fusobacteria;Fusobacteriales;Leptotrichiaceae;Leptotrichia_gid_126 7.97 10.31 12.10 1.30 (0.99, 1.72) 1.58 (1.10, 2.27) 0.010 0.055
Phylum Proteobacteria
Grammaproteobacteria;Pasteurellales;Pasteurellaceae 138.73 194.42 191.54 1.36 (1.12, 1.66) 1.37 (1.07, 1.76) 0.0064 0.052
Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter_gid_286 3.21 10.94 5.63 2.83 (1.93, 4.15) 1.81 (1.13, 2.89) 0.0024 0.027
Betaproteobacteria;Neisseriales;Neisseriaceae;Eikenella 1.33 2.20 1.75 1.71 (1.33, 2.19) 1.39 (1.00, 1.93) 0.0099 0.055
Betaproteobacteria;Neisseriales;Neisseriaceae;Kingella_gid_009 4.19 8.35 6.12 1.85 (1.38, 2.49) 1.55 (1.06, 2.27) 0.0057 0.042
Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria_gid_382 1.90 5.20 5.55 2.42 (1.55, 3.75) 2.12 (1.27, 3.54) 0.0024 0.027
Grammaproteobacteria;Cardiobacteriales;Cardiobacteriaceae;Cardiobacterium** 5.41 7.47 7.04 1.60 (1.27, 2.01) 1.41 (1.04, 1.92) 0.0047 0.041
  1. Sequence read counts were normalized by dividing raw counts by DESeq size factors
  2. Nominal p values from trend tests. In trend test, alcohol drinking was treated as a continuous variable by assigning the numbers 0, 1, and 2 to non-, moderate, and heavy drinkers, respectively. All taxa with an FDR-adjusted q < 0.10 are included in the table. See Additional file 1: Table S1 for mean counts and comparisons stratified by cohort
  3. §FDR-adjusted p value. FDR adjustment was conducted at each taxonomic level (i.e., class, genus) separately
  4. ||Association was significant up to family Bacteroidales[F-2], because this genus is the single constituent member of its family
  5. Association was significant up to family Corynebacteriaceae, because this genus is the single constituent member of its family
  6. **Association was significant up to order Cardiobacteriales, because this genus is the single constituent member of its order