Skip to main content

Advertisement

Fig. 2 | Microbiome

Fig. 2

From: Commensal microbiota modulate gene expression in the skin

Fig. 2

Gene ontology analysis identifies immune response terms enriched in DEGs. a REVIGO treemap showing cluster representatives of Biological Process GO terms that are significantly enriched in the DEGs (FDR-corrected p value < 0.05). Larger boxes indicate greater significance, as the box sizes are determined by the absolute value of the log10 p value. b Barplot depicting the number of DEGs in each of the high-level significant Biological Process GO terms from part A. c Heatmap of the log normalized gene expression of DEGs in the GO term “Innate Immune Response”. d Flow cytometry analysis of GF and SPF mice (n = 5 each) identified no significant differences between GF and SPF skin in regard to myeloid (CD11b+) cells, dendritic (CD11c+) cells, macrophages (F4-80+), neutrophils (Ly6G+), non-hematopoietic (CD45) cells, and T cells (CD3+). However, Ly6C+ monocytes were significantly increased in frequency in SPF compared to GF skin (T test, p value < 0.01). All populations (except CD45) were pre-gated on live, CD45+ cells

Back to article page