Fig. 4

Lung microbiome modules and HIV infection/COPD status. a Assignment of OTUs into modules of the lung cross-domain bacterial-fungal (CDBF) network. The CDBF network is comprised of six modules. OTUs uniquely appearing in HIV-infected (dark blue), HIV-uninfected (light blue), COPD negative (yellow), or COPD positive (green) samples are found across all modules with strong enrichment in module 5. The unique species names that appeared in module 5 are listed on the right. b Associations in module 5 of the lung CDBF network. The size of the nodes was scaled by the number of neighbors, the thickness of the edges marks association strength