Table 3 Network module significantly enriched in inferred human interactors
From: Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins
Module | Module proteins | Interactors | Inferred interactions | FusoSecretome proteins | Annotations |
|---|---|---|---|---|---|
9 | 74 | 13 | 188 | 64 | Immune response-regulating cell surface receptor signaling pathway (GO:0002768), cell-cell junction (GO:0005911) |
16 | 67 | 12 | 122 | 65 | Metal ion homeostasis (GO:0055065), cell surface (GO:0009986) |
19 | 80 | 15 | 260 | 55 | Cellular response to organonitrogen compound (GO:0071417), membrane raft (GO:0045121) |
42 | 140 | 19 | 312 | 56 | Endocytosis (GO:0006897), membrane raft (GO:0045121) |
74 | 113 | 26 | 78 | 26 | Extracellular structure organization (GO:0043062), cell surface (GO:0009986) |
78 | 292 | 54 | 752 | 100 | Immune response-regulating cell surface receptor signaling pathway (GO:0002768), cell surface (GO:0009986) |
89 | 45 | 10 | 169 | 48 | Immune response-activating cell surface receptor signaling pathway (GO:0002429), nucleolar ribonuclease P complex (GO:0005655) |
90 | 51 | 10 | 28 | 12 | I-kappaB kinase/NF-kappaB cascade (GO:0007249), inclusion body (GO:0016234) |
138 | 126 | 22 | 57 | 26 | I-kappaB kinase/NF-kappaB cascade (GO:0007249), perinuclear region of cytoplasm (GO:0048471) |
165 | 81 | 17 | 327 | 71 | Neuron projection guidance (GO:0097485), synapse (GO:0045202) |
194 | 38 | 12 | 119 | 48 | G1/S transition of mitotic cell cycle (GO:0000082), cyclin-dependent protein kinase holoenzyme complex (GO:0000307) |
216 | 47 | 11 | 261 | 80 | Blood coagulation (GO:0007596), membrane raft (GO:0045121) |
246 | 50 | 15 | 83 | 32 | T cell activation (GO:0042110), Golgi membrane (GO:0000139) |
277 | 25 | 7 | 7 | 2 | Collagen catabolic process (GO:0030574), extracellular matrix (GO:0031012) |
298 | 106 | 16 | 242 | 75 | Actin cytoskeleton organization (GO:0030036), Arp2/3 protein complex (GO:0005885) |
300 | 37 | 9 | 164 | 49 | Stress-activated MAPK cascade (GO:0051403), nuclear speck (GO:0016607) |
371 | 25 | 7 | 79 | 48 | Actin filament organization (GO:0007015), lamellipodium (GO:0030027) |
433 | 38 | 9 | 121 | 49 | Positive regulation of intracellular protein kinase cascade (GO:0010740), spindle (GO:0005819) |
451 | 40 | 9 | 55 | 34 | Mitotic cell cycle phase transition (GO:0044772), heterochromatin (GO:0000792) |
456 | 36 | 9 | 142 | 59 | Regulation of system process (GO:0044057), dendrite (GO:0030425) |
563 | 26 | 8 | 43 | 29 | Regulation of sequence-specific DNA binding transcription factor activity (GO:0051090), external side of plasma membrane (GO:0009897) |
571 | 42 | 11 | 206 | 53 | Cell cycle phase transition (GO:0044770), transcription factor complex (GO:0005667) |
577 | 33 | 10 | 66 | 48 | Complement activation (GO:0006956), ER membrane insertion complex (GO:0072379) |
587 | 17 | 6 | 109 | 46 | Axonogenesis (GO:0007409), signalosome (GO:0008180) |
615 | 36 | 11 | 26 | 10 | Response to unfolded protein (GO:0006986), perinuclear region of cytoplasm (GO:0048471) |
625 | 25 | 8 | 226 | 104 | Regulation of sequence-specific DNA binding transcription factor activity (GO:0051090), chromatin (GO:0000785) |
689 | 38 | 14 | 151 | 72 | Blood coagulation (GO:0007596), apical junction complex (GO:0043296) |
702 | 23 | 8 | 157 | 46 | Peptidyl-tyrosine phosphorylation (GO:0018108), nucleolar ribonuclease P complex (GO:0005655) |
745 | 18 | 6 | 113 | 46 | Axon guidance (GO:0007411), cell leading edge (GO:0031252) |
794 | 22 | 7 | 151 | 46 | Gamma-aminobutyric acid signaling pathway (GO:0007214), postsynaptic membrane (GO:0045211) |
831 | 15 | 6 | 129 | 45 | Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096), cell leading edge (GO:0031252 |