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Table 2 List of metabolites and pathways significantly altered between control and LOS infants at diagnosis (day 0)

From: Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls

  Metabolite Pathway Fold change Log2(FC) P value Adjusted P value
Increased in controls Sucrose Galactose metabolism 15.6 3.96 0.001 0.005
Raffinose Galactose metabolism 1963.1 10.94 0.001 0.014
18-Hydroxycortisol C21-steroid hormone biosynthesis and metabolism 10683 13.38 0.003 0.010
L-Glutamate Tryptophan metabolism 29.33 4.87 0.003 0.008
18-Oxocortisol C21-steroid hormone biosynthesis and metabolism 17551 14.10 0.005 0.013
Didemethylcitalopram N-Glycan degradation 6.14 2.62 0.007 0.021
L-alpha-Acetyl-N-normethadol Drug metabolism-cytochrome P450 676.77 9.40 0.009 0.226
Acetic acid C21-steroid hormone biosynthesis and metabolism 577.12 9.17 0.011 0.042
Lactose Galactose metabolism 11.66 3.54 0.033 0.123
3-Ketolactose Galactose metabolism 555.27 9.12 0.047 0.002
Increased in LOS 21-Hydroxy-5beta-pregnane-3,11,20-trione C21-steroid hormone biosynthesis and metabolism 0.004 −7.93 0.034 0.137
10,11-dihydro-leukotriene B4 Leukotriene metabolism 0.16 −2.68 0.034 0.153
Monoethylglycinexylidide Drug metabolism-cytochrome P450 0.29 −1.79 0.039 0.125
11-Deoxycortisol C21-steroid hormone biosynthesis and metabolism 0.004 −7.93 0.043 0.147
  1. Abbreviations: LOS late onset sepsis, FC fold change