Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls

Table 2 List of metabolites and pathways significantly altered between control and LOS infants at diagnosis (day 0)

	Metabolite	Pathway	Fold change	Log2(FC)	P value	Adjusted P value
Increased in controls	Sucrose	Galactose metabolism	15.6	3.96	0.001	0.005
	Raffinose	Galactose metabolism	1963.1	10.94	0.001	0.014
	18-Hydroxycortisol	C21-steroid hormone biosynthesis and metabolism	10683	13.38	0.003	0.010
	L-Glutamate	Tryptophan metabolism	29.33	4.87	0.003	0.008
	18-Oxocortisol	C21-steroid hormone biosynthesis and metabolism	17551	14.10	0.005	0.013
	Didemethylcitalopram	N-Glycan degradation	6.14	2.62	0.007	0.021
	L-alpha-Acetyl-N-normethadol	Drug metabolism-cytochrome P450	676.77	9.40	0.009	0.226
	Acetic acid	C21-steroid hormone biosynthesis and metabolism	577.12	9.17	0.011	0.042
	Lactose	Galactose metabolism	11.66	3.54	0.033	0.123
	3-Ketolactose	Galactose metabolism	555.27	9.12	0.047	0.002
Increased in LOS	21-Hydroxy-5beta-pregnane-3,11,20-trione	C21-steroid hormone biosynthesis and metabolism	0.004	−7.93	0.034	0.137
	10,11-dihydro-leukotriene B4	Leukotriene metabolism	0.16	−2.68	0.034	0.153
	Monoethylglycinexylidide	Drug metabolism-cytochrome P450	0.29	−1.79	0.039	0.125
	11-Deoxycortisol	C21-steroid hormone biosynthesis and metabolism	0.004	−7.93	0.043	0.147

ISSN: 2049-2618