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Table 2 Predictive selection model defined different bacterial composition in ME/CFS diagnostic groups

From: Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome

Diagnostic groups
Selected bacterial species
  In-sample Cross-Validation
AUC AUC ER (%) FP (%) FN (%)
ME/CFS (50) vs. control (50)
[Firmicutes] Coprococcus catus 0.831 0.684 36.72 40.00 33.43
[Firmicutes] Pseudoflavonifractor capillosus
[Firmicutes] Dorea formicigenerans
[Firmicutes] Faecalibacterium prausnitzii
[Firmicutes] Coprococcus catus 0.893 0.745 29.68 29.71 29.64
[Firmicutes] Pseudoflavonifractor capillosus
[Firmicutes] Dorea formicigenerans
[Firmicutes] Faecalibacterium prausnitzii
[Firmicutes] Clostridium asparagiforme
[Proteobacteria] Sutterella wadsworthensis
[Bacteroidetes] Alistipes putredinis
[Firmicutes] Anaerotruncus colihominis
ME/CFS + IBS (21) vs. control (50)
[Firmicutes] Faecalibacterium cf 0.771 0.571 33.09 18.57 69.38
[Bacteroidetes] Bacteroides vulgatus
[Firmicutes] Faecalibacterium cf 0.923 0.687 25.59 18.43 43.48
[Bacteroidetes] Bacteroides vulgatus
[Firmicutes] Faecalibacterium prausnitzii
[Bacteroidetes] Alistipes putredinis
[Firmicutes] Coprococcus catus
[Firmicutes] Faecalibacterium cf 1 0.791 24.31 18.28 39.40
[Bacteroidetes] Bacteroides vulgatus
[Firmicutes] Faecalibacterium prausnitzii
[Bacteroidetes] Alistipes putredinis
[Firmicutes] Coprococcus catus
[Firmicutes] Anaerostipes caccae
[Firmicutes] Dorea formicigenerans
[Firmicutes] Anaerotruncus colihominis
[Firmicutes] Clostridium asparagiforme
ME/CFS w/o IBS (29) vs. control (50)
[Bacteroidetes] Bacteroides caccae 0.775 0.589 40.67 25.29 66.30
[Firmicutes] Pseudoflavonifractor capillosus
[Bacteroidetes] Bacteroides caccae 0.948 0.754 28.41 21.07 40.65
[Firmicutes] Pseudoflavonifractor capillosus
[Bacteroidetes] Parabacteroides distasonis
[Bacteroidetes] Bacteroides fragilis
[Bacteroidetes] Prevotella buccalis
[Bacteroidetes] Bacteroides xylanisolvens
[Firmicutes] Dorea formicigenerans
ME/CFS w/o IBS (29) vs. ME/CFS + IBS (21)
[Bacteroidetes] Bacteroides vulgatus 0.913 0.604 37.61 29.30 50.08
[Bacteroidetes] Prevotella buccalis
[Firmicutes] Ruminococcus lactaris
[Firmicutes] Eubacterium hallii
[Firmicutes] Anaerotruncus colihominis
[Firmicutes] Faecalibacterium cf
[Firmicutes] Clostridium methylpentosum
[Bacteroidetes] Bacteroides vulgatus 0.956 0.604 41.51 27.32 62.80
[Bacteroidetes] Prevotella buccalis
[Firmicutes] Ruminococcus lactaris
[Firmicutes] Eubacterium hallii
[Firmicutes] Anaerotruncus colihominis
[Firmicutes] Faecalibacterium cf
[Firmicutes] Clostridium methylpentosum
[Firmicutes] Faecalibacterium prausnitzii
[Proteobacteria] Klebsiella pneumoniae
[Bacteroidetes] Parabacteroides distasonis
[Bacteroidetes] Prevotella copri
  1. The arrows represent the increased or decreased relative abundance of bacterial species in total ME/CFS, ME/CFS + IBS, ME/CFS w/o IBS (compared to controls). In the last comparison, the arrow represents changes in the ME/CFS without IBS group (compared to ME/CFS with IBS). ME/CFS myalgic encephalomyelitis/chronic fatigue syndrome, IBS irritable bowel syndrome, AUC area under the curve, ER error rate, FP false positive, FN false negative