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Table 2 Partial correlations between class-level taxa and brain regions controlling for total gray matter volume in IBS (N = 29)

From: Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome

Brain region

Firmicutes-associated Bacilli

Firmicutes-associated Clostridia

Bacteroidetes-associated Bacteroidia

 

r

p

r

p

r

p

Subcortical

 L thalamus

−.15

.461

−.40

.037

.36

.063

 L caudate nucleus

.28

.156

.49

.010

−.45

.017

 L putamen

.18

.376

.52

.006

−.53

.005

 R putamen

.11

.600

.42

.029

−.48

.012

 L pallidum

.30

.132

.37

.056

−.44

.023

 R pallidum

.35

.070

.36

.069

−.45

.019

 L NACC

.20

.326

.38

.052

−.45

.019

 R NACC

.42

.029

.53

.004

−.59

.001

 R CeB

−.20

.306

−.34

.080

.41

.032

Insula

 Horizontal ramus of the anterior segment of the lateral sulcus

.15

.462

−.42

.027

.35

.069

 R short insular gyrus

−.12

.535

−.51

.007

.44

.023

 Vertical ramus of the anterior segment of the lateral sulcus

−.20

.325

−.48

.012

.49

.009

Frontal

 R Orbital part of the inferior frontal gyrus

−.43

.025

−.43

.027

.49

.009

 R orbital gyrus

−.44

.020

−.39

.043

.47

.013

 R gyrus rectus

−.34

.083

−.47

.014

.46

.015

 R superior part of the precentral gyrus

−.23

.252

−.42

.031

.41

.033

 L triangular part of the inferior frontal gyrus

.46

.017

−.10

.604

.05

.790

Cingulate

 

 Posterior-ventral part of the cingulate gyrus

−.39

.043

−.11

.580

.07

.716

Parietal

 R supramarginal gyrus

.50

.008

.27

.167

−.28

.159

 L_parietal occipital sulci

.01

.969

−.50

.008

.45

.018

Temporal

 L temporal pole

−.39

.046

−.21

.284

.24

.228

 L planum polare of the superior temporal gyrus

−.07

.747

.41

.035

−.37

.060

 L lateral occipital temporal sulcus

−.02

.924

.45

.018

−.44

.021

Occipital

 L superior and transvers occipital sulci

.28

.153

.39

.043

−.45

.017

  1. Pearson’s correlation between relative abundance and brain volumes
  2. R=correlation, p=probability
  3. P values less than .05 uncorrected are bolded