Fig. 7

Post-transplanted intestinal microbial profiles and BP of recipient mice. a Schematic representation of fecal microbiota transplantation. GF mice (n = 5 for control, n = 10 for HTN) are orally inoculated with prepared fecal contents from two patients of HTN and one normotensive control, respectively. The gut microbial profiles are analyzed at 7 days, and BP is measured at 10 weeks post-transplantation. C, control; H, HTN. b Venn diagram comparing the shared genera number in gut microbiome of human donors (n = 1 for control, n = 2 for HTN) and recipient mice (n = 3 for control, n = 6 for HTN). c Shannon index of recipient mice at the genus level demonstrate significantly reduced α diversity in HTN group. P = 0.048 from t test. Boxes represent the inter quartile ranges, lines inside the boxes denote medians, and circles are outliers. d PCoA plots of human donors and recipient mice based on microbial genera separate HTN group from the controls. e Heat map comparing the abundance of altered genera between control and HTN mice. Red, more abundant; blue, less abundant. Genera present consistent trend with the metagenomic analysis are marked with green points, while inconsistent with gray points. f SBP, DBP, MBP, and HR of the recipient mice (n = 5 for control, n = 10 for HTN) are measured by tail-cuff method. Data are presented as mean ± s.e.m. P = 0.018, SBP; P = 0.019, DBP; P = 0.014, MBP; P = 0.11, HR; t test