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Table 3 Predicted toxin-antitoxin systems

From: Ancient bacteria of the Ötzi’s microbiome: a genomic tale from the Copper Age

Ancient ORFs TADB code TADB gene Subject Identity Aln-len Mismatch Gap openings Q.start Q.end S.start S.end Log (e value) Bit score Predicted annotation
CADE_0165 TADB|8353403 CLL_A3362 Clostridium botulinum B str. Eklund 17B 96.6 116 4 0 1 116 1 116 -57.5 216.9 mRNA interferase PemK
CADE_0166 Hypothetical protein
CALG_0512 TADB|8436183 CLH_2005 Clostridium botulinum E3 str. Alaska E43 76.7 146 34 0 1 146 1 146 −64.3 240 Hypothetical protein
CALG_0513 TADB|8436181 CLH_2004 Clostridium botulinum E3 str. Alaska E43 63.8 127 46 0 4 130 6 132 −45.3 176.4 Hypothetical protein
CALG_1265 TADB|375739 CAC0494 Clostridium acetobutylicum ATCC 824 90.4 114 11 0 3 116 2 115 −54.3 206.5 mRNA interferase PemK
CALG_1266 CopG family transcriptional regulator
CPER_1456 TADB|4710268 CPF_0812 Clostridium perfringens ATCC 13124 95.8 71 3 0 1 71 1 71 −35.6 144.4 Hypothetical protein
CPER_1457 TADB|607725 CPE0814 Clostridium perfringens str. 13 97.5 162 4 0 1 162 1 162 −87.9 318.2 GNAT family acetyltransferase
CPER_2012 TADB|4710831 CPF_1033 Clostridium perfringens ATCC 13124 99.4 168 1 0 1 168 1 168 −95.5 343.6 Hypothetical protein
CPER_2013 TADB|4710829 CPF_1032 Clostridium perfringens ATCC 13124 100 69 0 0 1 69 1 69 −34 139 DNA-binding protein
CPER_2208 TADB|4721113 CPR_0896 Clostridium perfringens SM101 97.2 143 4 0 1 143 1 143 −77.7 284.3 Hypothetical protein
CPER_3173 TADB|4710797 CPF_1020 Clostridium perfringens ATCC 13124 97.9 140 3 0 7 146 1 140 −75.2 275.8 Hypothetical protein
CPER_3174 TADB|4710799 CPF_1021 Clostridium perfringens ATCC 13124 95.6 180 8 0 1 180 1 180 −93.5 337 XRE family transcriptional regulator
PFLU_1561 TADB|9079447 PFLU2030 Pseudomonas fluorescens SBW25 98.4 123 2 0 1 123 1 123 −64.8 241.1 Hypothetical protein
PFLU_1562 TADB|9079443 PFLU2029 Pseudomonas fluorescens SBW25 88.5 113 12 1 1 112 1 113 −50.8 194.9 Cro/Cl family transcriptional regulator
PFLU_2731 Hexulose-6-phosphate isomerase
PFLU_2732 TADB|348443 hicB-2 Pseudomonas putida KT2440 71.3 108 31 0 5 112 2 109 −42.4 166.8 Antitoxin HicB
PFLU_4077 Protein RnfH
PFLU_4078 Ribosome association toxin RatA
PVER_0551 TADB|12012688 BCAS0580 Burkholderia cenocepacia J2315 55.8 129 56 1 1 128 1 129 −35.9 145.2 Twitching motility protein PilT
PVER_0552 AbrB family transcriptional regulator
PVER_1351 TADB|9070051 PFLU0443 Pseudomonas fluorescens SBW25 69.9 133 40 0 1 133 1 133 −50.8 194.9 Transcriptional regulator
PVER_1352 TADB|9070048 PFLU0442 Pseudomonas fluorescens SBW25 64.2 95 34 0 1 95 1 95 −33.8 138.3 Hypothetical protein
PVER_1942 Motility quorum-sensing regulator MqsR
PVER_1943 TADB|3146921 PFL_1052 Pseudomonas fluorescens Pf-5 58.1 136 55 1 1 136 1 134 −38.8 155.2 Transcriptional regulator
PVER_2079 TADB|9097595 PFLU5131 Pseudomonas fluorescens SBW25 94 84 5 0 1 84 19 102 −39.7 157.9 Prevent-host-death protein
PVER_2080 TADB|9097599 PFLU5132 Pseudomonas fluorescens SBW25 95.2 84 4 0 1 84 1 84 −44.9 175.3 Toxin YoeB
PVER_2187 Addiction module toxin RelE
PVER_2188 TADB|9082037 PFLU2450 Pseudomonas fluorescens SBW25 92 100 8 0 1 100 1 100 −47.6 184.1 Transcriptional regulator
PVER_2192 TADB|9082090 PFLU2458 Pseudomonas fluorescens SBW25 92.8 125 9 0 1 125 1 125 −62.2 232.6 Twitching motility protein PilT
PVER_2193 TADB|9082094 PFLU2459 Pseudomonas fluorescens SBW25 76.9 117 27 0 1 117 1 117 −47.4 183.3 Prevent-host-death protein
PVER_2252 TADB|348443 hicB-2 Pseudomonas putida KT2440 71.3 108 31 0 5 112 2 109 −42.4 166.8 Antitoxin HicB
PVER_2253 Hexulose-6-phosphate isomerase
PVER_2785 TADB|9079443 PFLU2029 Pseudomonas fluorescens SBW25 88.5 113 12 1 1 112 1 113 −50.8 194.9 Cro/Cl family transcriptional regulator
PVER_2786 TADB|9079447 PFLU2030 Pseudomonas fluorescens SBW25 98.4 123 2 0 1 123 1 123 −64.8 241.1 Hypothetical protein
PVER_3149 TADB|3145803 PFL_0652 Pseudomonas fluorescens Pf-5 78.7 94 20 0 1 94 1 94 −37.3 149.8 Addiction module antitoxin
PVER_3150 TADB|3145805 PFL_0653 Pseudomonas fluorescens Pf-5 59.6 99 40 0 1 99 12 110 −30.3 126.7 Addiction module protein
PVER_3532 TADB|9094658 PFLU4639 Pseudomonas fluorescens SBW25 91.5 117 10 0 1 117 2 118 −57 215.3 Transcriptional regulator
PVER_3533 TADB|9094655 PFLU4638 Pseudomonas fluorescens SBW25 88 100 12 0 1 100 1 100 −46.4 180.3 Toxin RelE
PVER_4905 Protein RnfH
PVER_4906 Ribosome association toxin RatA