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Table 1 Subject characteristics and pneumonia diagnosis

From: Composition and dynamics of the respiratory tract microbiome in intubated patients

Subject

Age

Sex

Chronic disease

Acute diagnosis

Days enrolled

CAP/HAP

VAP

Aspiration at enrollment

Subsequent aspiration

1

61

F

HCV cirrhosis

Sepsis (cx negative)

6

N

Y

Y

Y

2

25

F

AML post allo-BMT

Neutropenic sepsis (cx negative)

8

N

Y

N

N

3

61

M

Cardiomyopathy

PE + PEA arrest

1

N

N

N

–

4

32

F

Epilepsy

Seizure + aspiration

1

N

N

Y

–

5

77

F

ALS

Hypercarbia

10

N

Y

N

N

6

84

F

Metastatic NSCLC

Hypercarbia

5

N

N

Y

Y

7

42

F

Morbid obesity + OHS

Hypercarbia

15

N

Y

N

N

8

65

M

Hypertension

Acute AML

1

N

N

N

–

9

54

F

Asthma

Osteomyelitis + sepsis (cx negative)

1

Y

N

Y

–

10

69

F

ESRD on HD

MRSA sepsis

5

Y

N

N

N

11

60

M

COPD post OLT

Hypoxemia

2

N

N

N

N

12

65

F

AML post allo-BMT + GVHD

Sepsis (cx negative)

1

Y

N

Y

–

13

61

M

EtOH/HCV cirrhosis

Aspiration + sepsis (cx negative)

2

N

N

Y

N

14

49

F

Pancreatic cancer

Obtundation

2

N

N

N

N

15

57

F

Myelodysplastic syndrome

RSV pneumonia

9

Y

N

N

N

  1. Age, sex, underlying disease, and acute indication for mechanical ventilation are described for each enrolled subject. Cases of sepsis without a pathogen identified by blood culture are indicated (cx negative). The clinical diagnosis of LRTI, as ascertained by chart review of the MICU attending physician’s daily progress note, is presented for each subject. LRTI diagnosed within the first 48 h of intubation is categorized as CAP or HAP; LRTI diagnosed after 48 h of intubation is categorized as VAP [42]. Aspiration, likewise ascertained by chart review, is included and categorized as either a suspected contributor to the respiratory failure requiring intubation or as a complication occurring during the course of mechanical ventilation
  2. HCV hepatitis C virus, AML acute myelocytic leukemia, BMT bone marrow transplantation, PE pulmonary embolism, PEA pulseless electrical activity, ALS amyotrophic lateral sclerosis, NSCLC non-small cell lung cancer, OHS obesity hypoventilation syndrome, ESRD end-stage renal disease, HD hemodialysis, COPD chronic obstructive pulmonary disease, OLT orthotopic lung transplantation, GVHD graft-versus-host disease, EtOH alcohol, RSV respiratory syncytial virus