Fig. 7From: Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis Proposed model for the immune regulatory network that connects host, parasitic nematode, and SFB microbiota during N. brasiliensis infection in mice. We showed that SFB-colonized mice reduce SFB and expression of IL-17 upon infection with N. brasiliensis or induction with exogenous IL-25 in a way that is dependent on STAT6 activation by IL-13 and possibly modulation of intestinal AMP and mucin expression. This is consistent with a model in which the host type 2 response to parasite infection leads to SFB depletion with the net result of reduced intestinal IL-17 expressionBack to article page