Boxplot of the accuracy of CopyRighter's correction based on the composition of 16S rRNA gene amplicon mock datasets at the genus level. (A-C) In silico uneven Grinder datasets of varying richness, and (D,E) published in vitro mock datasets. The boxes represent the minimum, maximum, median and interquartile range. The smaller the distance, the closer the observed profile is to the expected profile. Corrected profiles with a significantly lower distance than the corresponding uncorrected profiles (unilateral exact Mann–Whitney test, P < 0.05) are marked with a star.