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Fig. 2 | Microbiome

Fig. 2

From: Human-associated bacteria adopt an unusual route for synthesizing 3-acetylated tetramates for environmental adaptation

Fig. 2

The different biosynthetic mechanisms of MUC and TeAs and their diverse ecological roles in hosts. MUC and RTC isolated from bacteria share a pyrrolidine-2,4-dione ring backbone with TeAs produced by fungi. MUC and RTC are generated through lactam bond formation differently from the prevalent Dieckmann cyclization mechanism as in TeAs. Strains containing the muc gene cluster, such as human oral bacteria S. mutans, can produce both the immunomodulator (MUC) and antibacterial agent (RTC), while the rtc gene cluster without mucF originally discovered in sourdough-generated L. reuteri can only produce RTC. Different Alternaria strains isolated from plants or insects can produce diverse TeAs with phytotoxic or antibacterial activities through the incorporation of different precursors

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Microbiome

ISSN: 2049-2618

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