Fig. 5

Class II bacteriocins are structurally diverse and variably prevalent in the human microbiome. a The number of putative precursors of class II bacteriocins detected by hmmsearch and BAGEL4. They identified 128,369 and 90,026 putative precursors, respectively, with 30,746 sequences in common. b Distribution of the length of 2,005 representative precursors, which cd-hit designated. c Rarefaction curve of clusters of class II bacteriocin precursors (blue line). The Red dashed line shows that 1,775 sequences belonging to 188 clusters were highly similar to known class II bacteriocins (identity > 90%, coverage > 95%). d Number of clusters in different genera (left), species (middle), and genomes (right). e, t-SNE plot reveals the distinct profile of class II bacteriocins in different body sites. Each dot represents one metagenome sample. f The prevalence and average abundance of 644 precursor clusters detected in six body sites. Each dot denotes one precursor cluster. The abundance in the individual is shown in Supplementary Fig. 17. The red numbers are the number of precursor clusters with a log2-transformed average abundance > -5 (shown in red dashed line) and the number of precursor clusters detected in each body site