Fig. 3

LAB BGCs in the human microbiome are variable and niche-specific. a The prevalence and abundance of LAB genera in the microbial communities of six body sites. The point size and color are proportionate to the genus prevalence and median abundance, respectively. b The GCF accumulation curve shows how the number of detected GCFs increases as more samples are included. The numbers of metagenomes of six body sites are as follows: anterior nares, 66; stool, 100; posterior fornix, 169; supragingival plaque, 281; buccal mucosa, 66; tongue dorsum, 66. c Number of GCFs detected in six body sites. Data are mean ± standard deviation, with only the upper error bar being shown. The color is indicated in the legend of (b). d Boxplot shows the abundance of different BGCs detected in six body sites. e The pie chart shows the proportion of 610 GCFs detected in how many sites and is distinguished using different colors. Corresponding percentages are shown in the brackets. The bar plot on the left refers to the number of GCFs in each site. The bar plot on the top depicts the number of GCFs of each intersection. Connecting lines are drawn if an intersection is present in more than one site. f Numbers of genus/species/genome-specific GCFs and cross-genus/species/genome GCFs that were detected in one site (niche-specific) or more than one sites (cross-niche). The Chi-squared test gave P values. *, 0.01 < P < 0.05; ***, P < 0.001