Fig. 5

Correlation of GC-enriched and GC-depleted genera associated with a mucin phenotype or aberrant MUC13 expression. Each sphere represents the bacterial network of gastric adenocarcinomas with A gastric mucin phenotype (n = 12), B intestinal mucin phenotype (n = 15), C mixed mucin phenotype (n = 41), D null mucin phenotype (n = 14), E low MUC13 mRNA expression (n = 26), and F high MUC13 mRNA expression (n = 34). Each genus found to participate in the bacterial community is represented by a point and connected through lines with interacting bacterial taxa. The red lines are positive associations between bacterial genera while the blue dotted lines are negative interactions. The point shape represents the association between a genus and a specific mucin (i.e., the genus is found to be differentially abundant with different expression levels of the mucin). The color of the point (+ genus name) represents the mucin mRNA expression level in which the genus was found to be enriched. If the genus was not found to be differentially abundant with different mucin expression levels, the shape is a full circle that is either gray (does not directly interact with other genera associated with a specific mucin) or black (the genus interacts directly with a mucin-associated bacterial taxa)