Fig. 5

The CBA/J database (CBAJ-DB) highlights differential metabolisms encoded in uninfected and inflamed mice. A Normalized relative abundance is shown by a heatmap. Values are mean GeTMM relative abundance of all MAGs with each function center scaled across rows. Functions that are significantly different between treatments as determined by analysis of variance (ANOVA) (p ≤ 0.05) are indicated by horizontal bars between heatmaps with red highlighting significance at the function (first bar) or functional group level (second bar). Gray bars on each heatmap indicate the number dereplicated medium- and high-quality (dMQHQ) MAGs that comprise at least 0.5% of the community with a given function. B Percent change in relative abundance (RA) between treatments the 17 most divergent MAGs. Points are colored by the treatment (uninfected, green; infected, brown) with higher RA. Individual MAGs are uniquely colored by surrounding boxes, acting as color legend for subsequent figure sections. C Individual MAG contribution to specific functions is shown, with bar magnitude denoting mean RA in either treatment. D Clostridia MAGs with mean RA greater than 0.5% in both treatments are shown. E Clostridia contribution to significant functions (top) and contribution of other taxa (bottom). Plot fields are colored by treatment and bar magnitude indicates mean RA within a treatment