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Fig. 2 | Microbiome

Fig. 2

From: Sialic acid exacerbates gut dysbiosis-associated mastitis through the microbiota-gut-mammary axis by fueling gut microbiota disruption

Fig. 2

Metabolic profiles of health and SARA cows. A PCA score plots for ruminal samples. The X axis and Y axis represent the percentages of contribution the first two principal components (PC1 and PC2) (n = 6). B Hierarchical cluster analysis of ruminal metabolites that were different between health and SARA cows (n = 6). C Volcano plots indicating the results of pairwise comparisons of metabolites in health and SARA cows (n = 6). The vertical and horizontal dashed lines indicate the threshold for the twofold abundance difference and the p = 0.05 threshold, respectively. Student’s t test was performed for the comparison. Significant metabolites are presented in red (upregulated) or green (downregulated) (VIP > 1, P value < 0.05 and FC ≥ 2 or FC ≤ 0.5). The relative expression levels of Neu5Gc (D) and Neu5Ac (E) in health and SARA samples were determined (n = 6). Each dot represents an individual and Student’s t test was performed, followed by Tukey test. ***p < 0.001. Neu5Gc, N-Glycolylneuraminic acid; VIP, variable importance in the projection

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Microbiome

ISSN: 2049-2618

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