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Fig. 3 | Microbiome

Fig. 3

From: Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward

Fig. 3

The alteration of the hedonic and learning components of food behavior associated with obesity is partially transferred by gut microbes. a Food preference test showing HFHS and CT intake every 15 min during 180 min of test and total HFHS intake after 180 min of test by lean (Lean_do) and DIO donor mice (DIO_do). b Food preference test showing HFHS and CT intake every 15 min during 180 min of test and total HFHS intake after 180 min of test by gut microbiota recipient mice from lean (Lean_rec) and diet-induced obese donor mice (DIO_rec). c Preference score of conditioned place preference based on the difference of time spent (s) in the palatable food-associated side vs the time spent in the neutral-associated side of the cage during the pre-test and the test by lean (Lean_do) or diet-induced obese donor mice (DIO_do). d Preference score of conditioned place preference based on the difference of time spent (s) in the palatable food-associated side vs the time spent in the neutral-associated side of the cage during the pre-test and the test by gut microbiota recipient mice from lean (Lean_rec) and diet-induced obese donor mice (DIO_rec). Data are shown as mean ± SEM (n=4–6/group). p-values were obtained after two-way ANOVA, followed by Bonferroni post hoc test (a,b) or after unpaired Student’s t test (a,b) or after paired Student’s t test (c,d). $: p-value ≤ 0.05 between CT vs HFHS intake in Lean_do and Lean_rec group, #: p-value ≤ 0.05 between CT vs HFHS intake in DIO_rec group, ***: p-value ≤ 0.001 between Lean_do group and DIO_do group *: p-value ≤ 0.05 between preference scores during test and pre-test

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