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Fig. 3 | Microbiome

Fig. 3

From: Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment

Fig. 3

Metagenomic functional analysis of potential psychobiotics. a Heatmap of Spearman’s correlation for key Kyoto Encyclopedia of Genes and Genomes ortholog groups (KOs) and psychological factor scores. The KOs whose correlation coefficient |R| was ≥ 0.5 (P < 0.001) in more than 50% of the psychological factors are shown here. The scaling of correlation coefficient is represented by color depth—a positive correlation is expressed in red and a negative correlation in blue. *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001. KOR, 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase; BUK, butyrate kinase; ENO, enolase; ENR, enoyl-[acyl-carrier protein] reductase; ECH, enoyl-CoA hydratase; HADH, 3-hydroxyacyl-CoA dehydrogenase; FUM, fumarate hydratase; FRD, fumarate reductase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MDH, malate dehydrogenase; MUT, methylmalonyl-CoA mutase; PTB, phosphate butyryltransferase; PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase; PK, pyruvate kinase; SUC, succinyl-CoA synthetase; PCCB, propionyl-CoA carboxylase beta chain; ABC.CD.P, putative ABC transport system permease protein; MSCS, small conductance mechanosensitive channel; KCH, voltage-gated potassium channel; RHAB, rhamnulokinase; TRKA, system potassium uptake protein; PRFB, peptide chain release factor 2; REX, redox-sensing transcriptional repressor; EARS, glutamyl-tRNA synthetase; CARS, cysteinyl-tRNA synthetase; RHAD, rhamnulose-1-phosphate aldolase; COAX, type 3 pantothenate kinase; PURM, phosphoribosylformylglycinamidine cyclo-ligase; RSMI, 16S rRNA (cytidine1402-2′-O)-methyltransferase; FUCO, lactaldehyde reductase; THAA, L-rhamnose isomerase; PFK, ATP-dependent phosphofructokinase/diphosphate-dependent phosphofructokinase; COBQ, adenosylcobyric acid synthase; XANP, xanthine permease; COBS, adenosylcobinamide-GDP ribazoletransferase; PCCA, propionyl-CoA carboxylase alpha chain; FABD, [acyl-carrier-protein] S-malonyltransferase; FABK, enoyl-acyl-carrier protein reductase II; ARGH, argininosuccinate lyase. b SCFA-producing metabolic pathways were constructed using the identified KOs. GTP, phosphoenolpyruvate carboxykinase; MCEE, methylmalonyl-CoA epimerase; PCC, propionyl-CoA carboxylase; PCT, propionate CoA transferase; PTA, phosphate acetyltransferase; ACK, acetate kinase; PFL, pyruvate formate-lyase; PFOR, pyruvate, ferredoxin oxidoreductase; ACS, acetyl-CoA synthase; ACK, acetate kinase; ACAT, acetyl-CoA acetyltransferase; BCoAT, butyryl CoA:acetate CoA transferase. c Pathways involving these 40 KOs in (a), generated using iPATH 3 (https://pathways.embl.de/). These pathways are positively correlated with positive emotions and negatively correlated with negative emotions

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