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Fig. 2 | Microbiome

Fig. 2

From: IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans

Fig. 2

IL-22Fc alters microbial tryptophan metabolism in mice. A Fecal concentrations of L-Trp, I3C, and 5-HIAA following IL-22Fc or aRW treatment. B Log2 fold change from baseline in fecal concentrations of L-Trp, I3C, and 5-HIAA. C Predicted metagenomic counts, as calculated by PICRUSt2, mapping to the L-tryptophan biosynthesis pathway in IL-22Fc or aRW-treated animals. D Predicted metagenomic counts, as calculated by PICRUSt2, of microbial enzymes capable of synthesizing tryptophan (tryptophan synthase), indole (tryptophanase), and 5-HIAA (aldehyde dehydrogenase). Statistical significance determined by rank-sum test (*p<0.05, **p<0.01). Triangle, square, and circle markers indicate ileal, colonic, and fecal samples, respectively. Teal and red markers indicate animals treated with IL-22Fc (n=8) or isotype control (n=8), respectively

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