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Fig. 4 | Microbiome

Fig. 4

From: Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10−/− mouse model of inflammatory bowel disease

Fig. 4

cART reduces histological score and MMTV viral load in colon tissues of IL-10 − / − mice. A Hematoxylin and eosin stain of colon tissues shows marked reduction in inflammation in the IL-10 − / − sample following cART to levels observed in the SvEv wild type. B Histological scoring of colon tissue samples (***p < 0.001, **p < 0.01). C Colon MMTV RNA load was reduced 25% in IL-10 − / − mice receiving cART vs. placebo; 42% of IL-10 − / − mice receiving cART developed background MMTV levels versus 10% of those on placebo (*p < 0.028, Fisher’s exact test. Cutoff = 2 × SD of background SvEv WT colon samples). D Colon weight-to-length ratio used as a surrogate of gut inflammation was evaluated after 12 weeks of treatment (mean ± SEM, **p = 0.0015)

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