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Fig. 2 | Microbiome

Fig. 2

From: Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10−/− mouse model of inflammatory bowel disease

Fig. 2

MMTV superantigen and cognate TCR-Vβ differences in IL-10 − / − vs. SvEv WT colon. A Phylogram of sag clones showing a predominance (92%) of mtv-9 that activates TCR-Vβ5 and TCR-Vβ12 (phylogenetic tree made by MacVector 18.5: neighbor joining; Best Tree; tie breaking = random; distance: uncorrected (“p”); gaps distributed proportionally). B TCR-Vβ5 and TCR-Vβ12 subset distribution of read count assessed by Illumina sequencing in spleen and colon showed no significant differences between IL-10 − / − vs. SvEv in the spleen, whereas IL-10 − / − colon had more than twofold % increase in TCR-Vβ5 and TCR-Vβ12 (mean ± SEM, **p = 0.006, multiple unpaired t-test, Benjamini, Kreiger, and Yekutieli two-stage setup)

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Microbiome

ISSN: 2049-2618

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