Fig. 1From: Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10−/− mouse model of inflammatory bowel diseaseIncreased viral load and immune responses to MMTV in IL-10 − / − and SvEv WT mouse. A RT-PCR of colon RNA shows increased relative MMTV copy number in IL-10 − / − vs. SvEv colon (relative units; **p = 0.004, Mann–Whitney test). B Interferon-γ release assay showing increased production in the IL-10 − / − vs. SvEv splenocytes without any stimulus (nil) and following stimulation with either MMTV Gag peptides or PMA/ionomycin (mean ± SEM, Gag, and PMA levels normalized to background production; *p = 0.05, **p = 0.002, unpaired t-test)Back to article page