Fig. 4

Pan-resistomes and core-resistomes. The length of the left and right bars describe the size of the pan- and core-resistome, respectively. The pan-resistome includes all genes encountered in at least one sample from the environment, and the core-resistome includes all genes that were commonly encountered (at least 50% of the samples). The colors indicate antibiotic type with higher opacity for latent ARGs and higher transparency for established ARGs. The computations were done based on rarefied metagenomes that, for each environment, were repeatedly subsampled down to 100 samples. The figure shows the average number of genes over all 100 samples. The labels Birds, Bovines, Mice, Pigs, Humans, and Infants denote metagenomes from the corresponding digestive system. Respiratory system and skin only include human samples