Fig. 4

Results of NEMoE on gut microbiome-PD study. a Coefficients of experts network in NEMoE at different taxonomic levels. The two latent classes showed distinctly different microbiome patterns. b Identification of diet-specific microbial signatures of PD. The “Same direction” class showed consistent function in different dietary patterns. The “PROT-carb only” and “prot-CARB only” classes tended to be important only with specific dietary intake. The “Different direction” class changed their coefficients in different dietary patterns. c Validation of differential relative abundance of genus Fusicatenibacter in 11 different datasets. With the exception of one dataset (Jin et al. [37]) all other datasets showed decreasing Fusicatenibacter in PD. d Forest plot of 95% confidence interval of selected taxa showed NEMoE is able to identify the species that are differentially represented in specific nutritional-ecotypes